Long term follow up of chronic hepatitis B patients after oral antiviral treatment discontinuation
DC Field | Value | Language |
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dc.contributor.author | Kang, Seong Hee | - |
dc.contributor.author | Yeon, Jong Eun | - |
dc.contributor.author | Lee, Young-Sun | - |
dc.contributor.author | Kim, Tae Suk | - |
dc.contributor.author | Yoo, Yang Jae | - |
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | Byun, Kwan Soo | - |
dc.date.available | 2021-01-13T06:44:46Z | - |
dc.date.issued | 201511 | - |
dc.identifier.issn | 0270-9139 | - |
dc.identifier.issn | 1527-3350 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/47341 | - |
dc.description.abstract | Introduction: In the current guidelines, 6-12 months of consolidation after the HBeAg seroconversion is recommended for HBeAg-positive patients. And the ideal treatment duration of HBeAg negative chronic hepatitis B (CHB) is not well known. We evaluated long term clinical courses in patient after antiviral treatment cessation. Methods: A total of 118 HBeAg-positive and 60 HBeAg-negative CHB patients who discontinued lamivudine between 1997 and 2014 were retrospectively analyzed. Results: In HBeAg-positive patients, the mean age of the patients at treatment initiation was 32.5 years. The mean duration of lamivudine treatment in was 32.3 months and the mean follow-up period after discontinuation was 72.4 months. The cumulative probability of a composite relapse (≥ 104 copies/ mL) at 1, 6, 12, 24, 48, 96, 180 months were 11.9%, 28.8%, 38.1%, 51.7%, 59.3%, 63.6%, 64.4% respectively. The mean duration of lamivudine treatment were 31.9 months and 32.9 months in the relapse and non-relapse group (p = 0.79). The mean duration of consolidation period after HBeAg seroconversion were 10.7 months and 11.4 months were not different (p = 0.792). Multivariate analysis revealed pretreatment age ≤ 34 years [HR 0.324, 95% CI: 0.148-0.710 p = 0.005] and undetectable HBV DNA [HR 0.261, 95% CI: 0.107-0.638 p = 0.003] within the three month after treatment discontinuation were the predictive factors of non-relapse. In HBeAg-negative patients, the mean age of the patients was 39.2 years. The cumulative probability of a composite relapse at 1, 6, 12, 24, 48, 96, 180 months were 25.0%, 33.3%, 35.0%, 41.7%, 43.3%, 46.7%, 48.3% respectively. Mean time to relapse after off-treatment was 13.6 months. The mean duration of lamivudine treatment were 29.8 months and 33.5 months in the relapse and non-relapse group (p = 0.447). Conclusions: Even with the long term consolidation after HBeAg seroconversion, most HBeAg positive CHB patients showed relapse. And half of patients with HBeAg-negative CHB had relapsed after treatment cessation. Antiviral therapy should be maintained for long term period or until HBsAg was lose. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | Long term follow up of chronic hepatitis B patients after oral antiviral treatment discontinuation | - |
dc.type | Conference | - |
dc.identifier.doi | 10.1002/hep.28242 | - |
dc.citation.title | Hepatology | - |
dc.citation.startPage | 1192A | - |
dc.citation.endPage | 1192A | - |
dc.citation.conferenceName | AASLD The Liver Meeting 2015 | - |
dc.citation.conferencePlace | 미국 | - |
dc.citation.conferencePlace | San Francisco, CA, USA | - |
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