Effects of online hemodiafiltration on anemia and nutritional status in chronic hemodialysis patients
DC Field | Value | Language |
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dc.contributor.author | Lee, Yu Ho | - |
dc.contributor.author | Shin, Yoon Soo | - |
dc.contributor.author | Lee, So-Young | - |
dc.contributor.author | Kim, Yang Gyun | - |
dc.contributor.author | Lee, Sang Ho | - |
dc.contributor.author | Moon, Ju Young | - |
dc.contributor.author | Jeong, Kyung Hwan | - |
dc.contributor.author | Hwang, Hyeon Seok | - |
dc.contributor.author | Ahn, Shin Young | - |
dc.contributor.author | Lee, Hong Joo | - |
dc.contributor.author | Lee, Dong-Young | - |
dc.contributor.author | Ko, Eun-Jung | - |
dc.contributor.author | Cho, Hye Jeong | - |
dc.contributor.author | Yang, Dong Ho | - |
dc.contributor.author | Jeong, Hye Yun | - |
dc.date.available | 2021-02-15T01:28:04Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 2211-9132 | - |
dc.identifier.issn | 2211-9140 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/49369 | - |
dc.description.abstract | Background: Online hemodiafiltration (OL-HDF) offers considerable advantages in clearance of molecules of various sizes. However, evidence of clinical effects of OL-HDF is scarce in Korea. In this study, we investigated changes in laboratory values over more than 12 months after switching to OL-HDF. Methods: Adult patients with end-stage renal disease undergoing hemodialysis (HD) were prospectively enrolled in a K-cohort (CRIS no. KCT0003281) from 6 tertiary hospitals in South Korea. We recruited 435 patients, 339 of whom were on HD at enrollment. One hundred eighty-two patients were followed for more than 24 months. Among them, 44 were switched to OL-HDF for more than 12 months without conversion to HD. We used a paired t test to compare baseline and 24-month follow-up results. Results: The mean age of the subjects was 61.2 +/- 12.2 years, and 62.6% were male. The baseline hemoglobin level was not significantly different between HD and OL-HDF group (10.61 +/- 1.15 vs. 10.46 +/- 1.03 g/dL, P = 0.437). However, the baseline serum protein and albumin levels were significantly lower in the OL-HDF group (6.82 +/- 0.49 vs. 6.59 +/- 0.48 g/dL, P= 0.006; 3.93 +/- 0.28 vs. 3.73 +/- 0.29 g/dL, P< 0.001). In patients switched to OL-HDF, levels of hemoglobin and serum albumin significantly increased (10.46 +/- 1.03 vs. 11.08 +/- 0.82 g/dL, P= 0.001; 3.73 +/- 0.29 vs. 3.87 +/- 0.30 g/dL, P = 0.001). The normalized protein catabolic rate decreased after 24 months, but the change was not significant (1.07 +/- 0.25 vs. 1.03 +/- 0.21 g/kg/day, P = 0.433). Although the dose of erythropoiesis-stimulating agent was lower in patients who converted to HDF, it was not significantly different (-115.7 +/- 189.7 vs. -170.5 +/- 257.1 P = 0.206). Conclusion: OL-HDF treatment over more than 12 months was associated with no harmful effects on anemia and nutritional status. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한신장학회 | - |
dc.title | Effects of online hemodiafiltration on anemia and nutritional status in chronic hemodialysis patients | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.23876/j.krcp.19.082 | - |
dc.identifier.scopusid | 2-s2.0-85083011244 | - |
dc.identifier.wosid | 000522214300013 | - |
dc.identifier.bibliographicCitation | Kidney Research and Clinical Practice, v.39, no.1, pp 103 - 111 | - |
dc.citation.title | Kidney Research and Clinical Practice | - |
dc.citation.volume | 39 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 103 | - |
dc.citation.endPage | 111 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002573883 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | esci | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | HIGH-FLUX HEMODIALYSIS | - |
dc.subject.keywordPlus | DIALYSIS THERAPY | - |
dc.subject.keywordPlus | KIDNEY-DISEASE | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | ACCESS | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordAuthor | Anemia | - |
dc.subject.keywordAuthor | Dialysis | - |
dc.subject.keywordAuthor | Kidney failure | - |
dc.subject.keywordAuthor | chronic | - |
dc.subject.keywordAuthor | Hemodiafiltration | - |
dc.subject.keywordAuthor | Nutritional status | - |
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