Beware of Early Relapse in Rectal Cancer Patients Treated With Preoperative Chemoradiotherapy
DC Field | Value | Language |
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dc.contributor.author | Oh, Seul-Gi | - |
dc.contributor.author | Park, In Ja | - |
dc.contributor.author | Seo, Ji-Hyun | - |
dc.contributor.author | Kim, Young Il | - |
dc.contributor.author | Lim, Seok-Byung | - |
dc.contributor.author | Kim, Chan Wook | - |
dc.contributor.author | Yoon, Yong Sik | - |
dc.contributor.author | Lee, Jong Lyul | - |
dc.contributor.author | Yu, Chang Sik | - |
dc.contributor.author | Kim, Jin Cheon | - |
dc.date.available | 2021-02-19T06:44:07Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 2287-9714 | - |
dc.identifier.issn | 2287-9722 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/51811 | - |
dc.description.abstract | Purpose: Recurrence patterns in rectal cancer patients treated with preoperative chemoradiotherapy (PCRT) are needed to evaluate for establishing tailored surveillance protocol. Methods: This study included 2,215 patients with locally-advanced mid and low rectal cancer treated with radical resection between January 2005 and December 2012. Recurrence was evaluated according to receipt of PCRT; PCRT group (n=1,258) and no-PCRT group (n=957). Early recurrence occurred within 1 year of surgery and late recurrence after 3 years. The median follow-up duration was 65.7 +/- 29 months. Results: The overall recurrence rate was similar between the PCRT and no-PCRT group (25.8% vs. 24.9%, P=0.622). The most common initial recurrence site was the lungs in both groups ( 50.6% vs. 49.6%, P=0.864), followed by the liver, which was more common in the no-PCRT group (22.5% vs. 33.6%, P=0.004). Most of the recurrence occurred within 3 years after surgery in both groups (85.3% vs. 85.8%, P=0.862). Early recurrence was more common in the PCRT group than in the no-PCRT group (43.1% vs. 32.4%, P=0.020). Recurrence within the first 6 months after surgery was significantly higher in the PCRT group than in the no-PCRT group (18.8% vs. 7.6%, P=0.003). Lung (n=27, 44.3%) and liver (n=22, 36.1%) were the frequent the first relapsed site within 6 months after surgery in PCRT group. Conclusion: Early recurrence within the first 1 year after surgery was more common in patients treated with PCRT. This difference would be considered for surveillance protocols and need to be evaluated in further studies. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC COLOPROCTOLOGY | - |
dc.title | Beware of Early Relapse in Rectal Cancer Patients Treated With Preoperative Chemoradiotherapy | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3393/ac.2020.06.11 | - |
dc.identifier.scopusid | 2-s2.0-85100118687 | - |
dc.identifier.wosid | 000605717600005 | - |
dc.identifier.bibliographicCitation | ANNALS OF COLOPROCTOLOGY, v.36, no.6, pp 382 - 389 | - |
dc.citation.title | ANNALS OF COLOPROCTOLOGY | - |
dc.citation.volume | 36 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 382 | - |
dc.citation.endPage | 389 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | esci | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | TOTAL MESORECTAL EXCISION | - |
dc.subject.keywordPlus | PHASE-III TRIAL | - |
dc.subject.keywordPlus | ADJUVANT CHEMOTHERAPY | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | POSTOPERATIVE CHEMORADIOTHERAPY | - |
dc.subject.keywordPlus | CURATIVE RESECTION | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | LOCAL RECURRENCE | - |
dc.subject.keywordPlus | STAGE-II | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | Rectal neoplasms | - |
dc.subject.keywordAuthor | Early recurrence | - |
dc.subject.keywordAuthor | Preoperative chemoradiotherapy | - |
dc.subject.keywordAuthor | Surveillance | - |
dc.subject.keywordAuthor | Recurrence pattern | - |
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