Discovery of a novel series of N-hydroxypyridone derivatives protecting astrocytes against hydrogen peroxide-induced toxicity via improved mitochondrial functionality
DC Field | Value | Language |
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dc.contributor.author | Singh, Sarbjit | - |
dc.contributor.author | Goo, Ja-Il | - |
dc.contributor.author | Noh, Hyojin | - |
dc.contributor.author | Lee, Sung Jae | - |
dc.contributor.author | Kim, Myoung Woo | - |
dc.contributor.author | Park, Hyejun | - |
dc.contributor.author | Jalani, Hitesh B. | - |
dc.contributor.author | Lee, Kyeong | - |
dc.contributor.author | Kim, Chunsook | - |
dc.contributor.author | Kim, Won-Ki | - |
dc.contributor.author | Ju, Chung | - |
dc.contributor.author | Choi, Yongseok | - |
dc.date.available | 2020-11-02T08:51:00Z | - |
dc.date.issued | 2017-02-15 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.issn | 1464-3391 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5268 | - |
dc.description.abstract | Astrocytes play a key role in brain homeostasis, protecting neurons against neurotoxic stimuli such as oxidative stress. Therefore, the neuroprotective therapeutics that enhance astrocytic functionality has been regarded as a promising strategy to reduce brain damage. We previously reported that ciclopirox, a well-known antifungal N-hydroxypyridone compound, protects astrocytes from oxidative stress by enhancing mitochondrial function. Using the N-hydroxypyridone scaffold, we have synthesized a series of cytoprotective derivatives. Mitochondrial activity assay showed that N-hydroxypyridone derivatives with biphenyl group have comparable to better protective effects than ciclopirox in astrocytes exposed to H2O2. N-hydroxypyridone derivatives, especially 11g, inhibited membrane-induced deterioration of mitochondrial membrane potential and oxygen consumption rate, and significantly improved cell viability of astrocytes. The results indicate that the N-hydroxypyridone motif can provide a novel cytoprotective scaffold for astrocytes via enhancing mitochondrial functionality. (C) 2017 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Discovery of a novel series of N-hydroxypyridone derivatives protecting astrocytes against hydrogen peroxide-induced toxicity via improved mitochondrial functionality | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.bmc.2016.12.052 | - |
dc.identifier.scopusid | 2-s2.0-85009761241 | - |
dc.identifier.wosid | 000394632100010 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY, v.25, no.4, pp 1394 - 1405 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY | - |
dc.citation.volume | 25 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1394 | - |
dc.citation.endPage | 1405 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | DJ-1 KNOCK-DOWN | - |
dc.subject.keywordPlus | CICLOPIROX OLAMINE | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | NEUROPROTECTION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | ROTENONE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | CURVES | - |
dc.subject.keywordAuthor | Ciclopirox | - |
dc.subject.keywordAuthor | N-hydroxypyridone | - |
dc.subject.keywordAuthor | Astrocytes | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Neuroprotection | - |
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