Detailed Information

Cited 15 time in webofscience Cited 14 time in scopus
Metadata Downloads

Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons

Full metadata record
DC FieldValueLanguage
dc.contributor.authorKim, Sun-Gyun-
dc.contributor.authorLee, Suho-
dc.contributor.authorKim, Yangsik-
dc.contributor.authorPark, Jieun-
dc.contributor.authorWoo, Doyeon-
dc.contributor.authorKim, Dayeon-
dc.contributor.authorLi, Yan-
dc.contributor.authorShin, Wangyong-
dc.contributor.authorKang, Hyunjeong-
dc.contributor.authorYook, Chaehyun-
dc.contributor.authorLee, Minji-
dc.contributor.authorKim, Kyungdeok-
dc.contributor.authorRoh, Junyeop Daniel-
dc.contributor.authorRyu, Jeseung-
dc.contributor.authorJung, Hwajin-
dc.contributor.authorUm, Seung Min-
dc.contributor.authorYang, Esther-
dc.contributor.authorKim, Hyun-
dc.contributor.authorHan, Jinju-
dc.contributor.authorHeo, Won Do-
dc.contributor.authorKim, Eunjoon-
dc.date.accessioned2021-07-09T06:40:25Z-
dc.date.available2021-07-09T06:40:25Z-
dc.date.issued2021-05-11-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/53780-
dc.description.abstractmTOR signaling, involving mTORC1 and mTORC2 complexes, critically regulates neural development and is implicated in various brain disorders. However, we do not fully understand all of the upstream signaling components that can regulate mTOR signaling, especially in neurons. Here, we show a direct, regulated inhibition of mTOR by Tanc2, an adaptor/scaffolding protein with strong neurodevelopmental and psychiatric implications. While Tanc2-null mice show embryonic lethality, Tanc2-haploinsufficient mice survive but display mTORC1/2 hyperactivity accompanying synaptic and behavioral deficits reversed by mTOR-inhibiting rapamycin. Tanc2 interacts with and inhibits mTOR, which is suppressed by mTOR-activating serum or ketamine, a fast-acting antidepressant. Tanc2 and Deptor, also known to inhibit mTORC1/2 minimally affecting neurodevelopment, distinctly inhibit mTOR in early- and late-stage neurons. Lastly, Tanc2 inhibits mTORC1/2 in human neural progenitor cells and neurons. In summary, our findings show that Tanc2 is a mTORC1/2 inhibitor affecting neurodevelopment. Alterations of the mTOR signalling pathway are associated with neurodevelopmental defects. Regulators of the mTOR kinase activity are not fully described. Here, the authors show that Tanc2, a scaffolding protein, acts as a direct inhibitor of mTOR kinase activity in the developing mouse brain and cultured human neurons.-
dc.language영어-
dc.language.isoENG-
dc.publisherNATURE RESEARCH-
dc.titleTanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons-
dc.typeArticle-
dc.publisher.location독일-
dc.identifier.doi10.1038/s41467-021-22908-4-
dc.identifier.scopusid2-s2.0-85105770875-
dc.identifier.wosid000658724200010-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, v.12, no.1-
dc.citation.titleNATURE COMMUNICATIONS-
dc.citation.volume12-
dc.citation.number1-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusDE-NOVO MUTATIONS-
dc.subject.keywordPlusDENDRITIC SPINES-
dc.subject.keywordPlusRISK GENES-
dc.subject.keywordPlusAUTISM-
dc.subject.keywordPlusDYSREGULATION-
dc.subject.keywordPlusDISABILITIES-
dc.subject.keywordPlusLABORAS(TM)-
dc.subject.keywordPlusVALIDATION-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusCOMPLEXES-
Files in This Item
There are no files associated with this item.
Appears in
Collections
1. Basic Science > Department of Anatomy > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Hyun photo

Kim, Hyun
College of Medicine (Department of Anatomy)
Read more

Altmetrics

Total Views & Downloads

BROWSE