Novel Paju Apodemus paramyxovirus 1 and 2, harbored by Apodemus agrarius in the Republic of Korea
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung-Ho | - |
dc.contributor.author | No, Jin Sun | - |
dc.contributor.author | Kim, Kijin | - |
dc.contributor.author | Budhathoki, Shailesh | - |
dc.contributor.author | Park, Kyungmin | - |
dc.contributor.author | Lee, Geum-Young | - |
dc.contributor.author | Cho, Seungchan | - |
dc.contributor.author | Kim, Bong-Hyun | - |
dc.contributor.author | Cho, Seunghee | - |
dc.contributor.author | Kim, Jongwoo | - |
dc.contributor.author | Lee, Jingyeong | - |
dc.contributor.author | Cho, Seung Hye | - |
dc.contributor.author | Kim, Heung-Chul | - |
dc.contributor.author | Klein, Terry A. | - |
dc.contributor.author | Uhm, Chang-Sub | - |
dc.contributor.author | Kim, Won-Keun | - |
dc.contributor.author | Song, Jin-Won | - |
dc.date.accessioned | 2021-08-17T08:40:27Z | - |
dc.date.available | 2021-08-17T08:40:27Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 0042-6822 | - |
dc.identifier.issn | 1089-862X | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/54018 | - |
dc.description.abstract | Paramyxoviruses harbored by multiple natural reservoirs pose a potential threat to public health. Jeilongvirus has been proposed as a novel paramyxovirus genus found in rodents, bats, and cats. Paramyxovirus RNA was detected in 108/824 (13.1%) Apodemus agrarius captured at 14 trapping sites in the Republic of Korea. We first present two genetically distinct novel paramyxoviruses, Paju Apodemus paramyxovirus 1 (PAPV-1) and 2 (PAPV-2). The disparity between PAPV-1 (19,716 nucleotides) and -2 (17,475 nucleotides) revealed the presence of the SH gene and length of the G gene in the genome organization. The phylogeny of PAPV-1 and -2 belonged to distinct genetic lineages of Jeilongvirus, respectively, even though these viruses were originated from A. agrarius. PAPV-1 infected human epithelial and endothelial cells, facilitating the induction of type I/III interferons, interferon-stimulated genes, and pro-inflammatory cytokines. Therefore, this study provides insights into the molecular epidemiology, genetic diversity, and virus-host interactions of novel rodent-borne paramyxoviruses. © 2021 | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Academic Press Inc. | - |
dc.title | Novel Paju Apodemus paramyxovirus 1 and 2, harbored by Apodemus agrarius in the Republic of Korea | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.virol.2021.06.011 | - |
dc.identifier.scopusid | 2-s2.0-85109672951 | - |
dc.identifier.wosid | 000692542800005 | - |
dc.identifier.bibliographicCitation | Virology, v.562, pp 40 - 49 | - |
dc.citation.title | Virology | - |
dc.citation.volume | 562 | - |
dc.citation.startPage | 40 | - |
dc.citation.endPage | 49 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordPlus | SMALL HYDROPHOBIC PROTEIN | - |
dc.subject.keywordPlus | COMPLETE GENOME SEQUENCE | - |
dc.subject.keywordPlus | N-GLYCANS | - |
dc.subject.keywordPlus | ANTIBODY NEUTRALIZATION | - |
dc.subject.keywordPlus | STALK DOMAIN | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | FUSION | - |
dc.subject.keywordPlus | ENTRY | - |
dc.subject.keywordPlus | COEXISTENCE | - |
dc.subject.keywordPlus | DIVERSITY | - |
dc.subject.keywordAuthor | Apodemus agrarius | - |
dc.subject.keywordAuthor | Paju Apodemus paramyxovirus 1 | - |
dc.subject.keywordAuthor | Paju Apodemus paramyxovirus 2 | - |
dc.subject.keywordAuthor | Phylogenetic diversity | - |
dc.subject.keywordAuthor | Rodent paramyxovirus | - |
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