Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein improves diagnostic accuracy for hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | Lee, Han Ah | - |
dc.contributor.author | Lee, Yoo Ra | - |
dc.contributor.author | Lee, Young-Sun | - |
dc.contributor.author | Jung, Young Kul | - |
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | An, Hyunggin | - |
dc.contributor.author | Yim, Hyung Joon | - |
dc.contributor.author | Jeen, Yoon Tae | - |
dc.contributor.author | Yeon, Jong Eun | - |
dc.contributor.author | Byun, Kwan Soo | - |
dc.contributor.author | Seo, Yeon Seok | - |
dc.date.accessioned | 2021-09-17T02:40:18Z | - |
dc.date.available | 2021-09-17T02:40:18Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.issn | 2219-2840 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/54242 | - |
dc.description.abstract | BACKGROUND Diagnostic accuracy of various tumor markers and their combinations for hepatocellular carcinoma (HCC) was not fully investigated. AIM To evaluate the diagnostic accuracy of alpha-fetoprotein (AFP), the Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3), and protein induced by vitamin K absence or antagonist-II (PIVKA-II) and their combination for HCC diagnosis. METHODS Patients with newly detected liver mass or elevated serum AFP levels were considered eligible. Serum AFP level, AFP-L3 fraction, and PIVKA-II level were measured at the first visit. RESULTS In total, 622 patients were included; 355 patients (57.1%) had chronic liver disease, and 208 (33.4%) had liver cirrhosis. HCC was diagnosed in 160 patients (25.7%). The area under the receiver operating characteristics curves (AUROCs) of the serum AFP, AFP-L3 fraction, AFP-L3, and PIVKA-II levels for the diagnosis of HCC were 0.775, 0.792, 0.814, and 0.834, respectively. A novel diagnostic model was developed by classifying patients in a 1:1 ratio into training and validation sets. Using the binary regression analysis of the training cohort, the AFP, AFP-L3 fraction, and PIVKA-II (ALPs) score was calculated as follows: ALPs score = 3.8 × [serum AFP level (ng/mL) × AFP-L3 fraction (%) × 0.01] + 0.2 × PIVKA-II level (mAU/mL). The AUROC of the ALPs score for diagnosis of HCC was 0.878, significantly higher than that of serum AFP level (P < 0.001), AFP-L3 fraction (P < 0.001), PIVKA-II level (P = 0.036), and AFP-L3 level (P = 0.006). The optimal ALPs score cut-off was 5.3 (sensitivity, 85.0%, specificity 80.1%). The validation cohort showed similar results. CONCLUSION The ALPs score calculated using serum AFP level, AFP-L3 fraction, and PIVKA-II level showed improved accuracy in HCC diagnosis. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Baishideng Publishing Group | - |
dc.title | Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein improves diagnostic accuracy for hepatocellular carcinoma | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.3748/wjg.v27.i28.4687 | - |
dc.identifier.scopusid | 2-s2.0-85111187045 | - |
dc.identifier.wosid | 000683005300011 | - |
dc.identifier.bibliographicCitation | World Journal of Gastroenterology, v.27, no.28, pp 4687 - 4696 | - |
dc.citation.title | World Journal of Gastroenterology | - |
dc.citation.volume | 27 | - |
dc.citation.number | 28 | - |
dc.citation.startPage | 4687 | - |
dc.citation.endPage | 4696 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | GAMMA-CARBOXY PROTHROMBIN | - |
dc.subject.keywordPlus | PIVKA-II | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | MARKER | - |
dc.subject.keywordPlus | AFP-L3 | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | UTILITY | - |
dc.subject.keywordPlus | SERUM | - |
dc.subject.keywordAuthor | Alpha-fetoprotein | - |
dc.subject.keywordAuthor | Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein | - |
dc.subject.keywordAuthor | Protein induced by vitamin K absence or antagonist-II | - |
dc.subject.keywordAuthor | Hepatocellular carcinoma | - |
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