Effect of beta-blocker therapy in patients with or without left ventricular systolic dysfunction after acute myocardial infarction
DC Field | Value | Language |
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dc.contributor.author | Joo, Seung-Jae | - |
dc.contributor.author | Kim, Song-Yi | - |
dc.contributor.author | Choi, Joon-Hyouk | - |
dc.contributor.author | Park, Hyeung Keun | - |
dc.contributor.author | Beom, Jong Wook | - |
dc.contributor.author | Lee, Jae-Geun | - |
dc.contributor.author | Chae, Shung Chull | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.contributor.author | Kim, Young Jo | - |
dc.contributor.author | Cho, Myeong Chan | - |
dc.contributor.author | Kim, Chong Jin | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.contributor.author | Yoon, Junghan | - |
dc.contributor.author | Jeong, Myung Ho | - |
dc.contributor.author | KAMIR-NIH Registry Investigators | - |
dc.date.accessioned | 2021-12-13T05:40:17Z | - |
dc.date.available | 2021-12-13T05:40:17Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 2055-6837 | - |
dc.identifier.issn | 2055-6845 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/54878 | - |
dc.description.abstract | Aims This observational study aimed to investigate the association between beta-blocker therapy and clinical outcomes in patients with acute myocardial infarction (AMI), especially with mid-range or preserved left ventricular systolic function. Methods and results Among 13 624 patients enrolled in the Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH), 12 200 in-hospital survivors were selected. Patients with beta-blockers showed significantly lower 1-year major adverse cardiac events (MACE), which was a composite of cardiac death, MI, revascularization, and readmission due to heart failure [9.7 vs. 14.3/100 patient-year; hazard ratio (HR) 0.84, 95% confidence interval (CI) 0.72-0.97; P=0.022). However, this association had a significant interaction with left ventricular ejection fraction (LVEF). Beta-blocker therapy at discharge was associated with lower 1-year MACE in patients with LVEF <= 40% (HR 0.63, 95% CI 0.48-0.81; P<0.001), and 40% = 50% (HR 1.16, 95% CI 0.91-1.48; P=0.234). Conclusions Beta-blocker therapy at discharge was associated with better 1-year clinical outcomes in patients with reduced or mid-range LVEF after AMI, but not in patients with preserved LVEF. These data suggested that the long-term beta-blocker therapy may be guided by LVEF. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | Effect of beta-blocker therapy in patients with or without left ventricular systolic dysfunction after acute myocardial infarction | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1093/ehjcvp/pvaa029 | - |
dc.identifier.scopusid | 2-s2.0-85120624312 | - |
dc.identifier.wosid | 000720749900006 | - |
dc.identifier.bibliographicCitation | EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY, v.7, no.6, pp 475 - 482 | - |
dc.citation.title | EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY | - |
dc.citation.volume | 7 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 475 | - |
dc.citation.endPage | 482 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | PRESERVED EJECTION FRACTION | - |
dc.subject.keywordPlus | CORONARY-ARTERY-DISEASE | - |
dc.subject.keywordPlus | ST-SEGMENT ELEVATION | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | HEART-FAILURE | - |
dc.subject.keywordPlus | TASK-FORCE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | ESC | - |
dc.subject.keywordAuthor | Beta-blockers | - |
dc.subject.keywordAuthor | Myocardial infarction | - |
dc.subject.keywordAuthor | Ventricular ejection fraction | - |
dc.subject.keywordAuthor | Outcome | - |
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