Changes in Metabolic Syndrome Status are Associated With Altered Risk of Pancreatic Cancer: A Nationwide Cohort Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Joo-Hyun | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Hong, Jung Yong | - |
dc.contributor.author | Park, Young Suk | - |
dc.contributor.author | Hur, Kyu Yeon | - |
dc.contributor.author | Kang, Gunseog | - |
dc.contributor.author | Park, Joon Oh | - |
dc.date.accessioned | 2022-02-25T01:49:20Z | - |
dc.date.available | 2022-02-25T01:49:20Z | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 0016-5085 | - |
dc.identifier.issn | 1528-0012 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/55218 | - |
dc.description.abstract | BACKGROUND AND AIMS: Metabolic syndrome (MetS) is reversible; however, the effect of changes in MetS status on pancreatic cancer risk is unknown. We aimed to investigate the effects of changes and persistence in MetS status on pancreatic cancer risk. METHODS: This nationwide cohort study included 8,203,492 adults without cancer who underwent 2 consecutive biennial health screenings provided by the Korean National Health Insurance System between 2009 and 2012 and were followed up until 2017. MetS was defined as the presence of 3 of its 5 components, which were evaluated at 2 consecutive biennial health screenings. Participants were categorized into the MetS-free, MetS-recovered, MetS-developed, or MetS-persistent group. Multivariable Cox proportional hazards regression models were used. RESULTS: During the 40,464,586 person-years of follow-up (median, 5.1 years), 8010 individuals developed pancreatic cancer. Compared with the MetS-free group, the MetS-persistent group had the highest risk of pancreatic cancer (hazard ratio [HR], 1.30; 95% confidence interval [CI], 1.23-1.37), followed by the MetS-developed group (HR, 1.17; 95% CI, 1.09-1.25) and the MetS-recovered group (HR, 1.12; 95% CI, 1.04-1.21) after adjusting for potential confounders (P for trend <.001). The MetS-recovered group was associated with a lower risk of pancreatic cancer than that in the MetS-persistent group (P < .001). The association between changes in MetS status and pancreatic cancer risk did not differ according to sex or obesity (all P for interactions >.05). CONCLUSIONS: In this study, recovering from MetS was associated with a reduced risk of pancreatic cancer compared with persistent MetS, suggesting that pancreatic cancer risk can be altered by changes in MetS. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | W. B. Saunders Co., Ltd. | - |
dc.title | Changes in Metabolic Syndrome Status are Associated With Altered Risk of Pancreatic Cancer: A Nationwide Cohort Study | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1053/j.gastro.2021.09.070 | - |
dc.identifier.scopusid | 2-s2.0-85121206061 | - |
dc.identifier.wosid | 000747814900021 | - |
dc.identifier.bibliographicCitation | Gastroenterology, v.162, no.2, pp 509 - + | - |
dc.citation.title | Gastroenterology | - |
dc.citation.volume | 162 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 509 | - |
dc.citation.endPage | + | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordAuthor | Pancreatic Neoplasms | - |
dc.subject.keywordAuthor | Risk Factors | - |
dc.subject.keywordAuthor | Malignant Tumor | - |
dc.subject.keywordAuthor | Prevention | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.