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[11C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome a pilot study

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dc.contributor.authorJeon S.Y.-
dc.contributor.authorSeo S.-
dc.contributor.authorLee J.S.-
dc.contributor.authorChoi S.-H.-
dc.contributor.authorLee D.-H.-
dc.contributor.authorJung Y.-H.-
dc.contributor.authorSong M.-K.-
dc.contributor.authorLee K.-J.-
dc.contributor.authorKim Y.C.-
dc.contributor.authorKwon H.W.-
dc.contributor.authorIm H.-J.-
dc.contributor.authorLee D.S.-
dc.contributor.authorCheon G.J.-
dc.contributor.authorKang D.-H.-
dc.date.available2020-11-02T10:41:02Z-
dc.date.issued2017-01-
dc.identifier.issn0025-7974-
dc.identifier.issn1536-5964-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5655-
dc.description.abstractComplex regional pain syndrome (CRPS) is characterized by severe and chronic pain, but the pathophysiology of this disease are not clearly understood. The primary aim of our case-control study was to explore neuroinflammation in patients with CRPS using positron emission tomography (PET), with an 18-kDa translocator protein specific radioligand [11C]-(R)-PK11195. [11C]-(R)-PK11195 PET scans were acquired for 11 patients with CRPS (30-55 years) and 12 control subjects (30-52 years). Parametric image of distribution volume ratio (DVR) for each participant was generated by applying a relative equilibrium-based graphical analysis. The DVR of [11C]-(R)-PK11195 in the caudate nucleus (t(21) = - 3.209, P=0.004), putamen (t(21) = - 2.492, P=0.022), nucleus accumbens (t(21) = -2.218, P=0.040), and thalamus (t(21) = -2.395, P=0.026) were significantly higher in CRPS patients than in healthy controls. Those of globus pallidus (t(21) = -2.045, P=0.054) tended to be higher in CRPS patients than in healthy controls. In patients with CRPS, there was a positive correlation between the DVR of [11C]-(R)-PK11195 in the caudate nucleus and the pain score, the visual analog scale (r=0.661, P=0.026, R2 = 0.408) and affective subscales of McGill Pain Questionnaire (r=0.604, P= 0.049, R2 = 0.364). We demonstrated that neuroinflammation of CRPS patients in basal ganglia. Our results suggest that microglial pathology can be an important pathophysiology of CRPS. Association between the level of caudate nucleus and pain severity indicated that neuroinflammation in this region might play a key role. These results may be essential for developing effective medical treatments. Copyright © 2017 the Author(s).-
dc.language영어-
dc.language.isoENG-
dc.publisherLippincott Williams and Wilkins-
dc.title[11C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome a pilot study-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1097/MD.0000000000005735-
dc.identifier.scopusid2-s2.0-85013830606-
dc.identifier.wosid000392083900033-
dc.identifier.bibliographicCitationMedicine (United States), v.96, no.1-
dc.citation.titleMedicine (United States)-
dc.citation.volume96-
dc.citation.number1-
dc.type.docTypeArticle-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaGeneral & Internal Medicine-
dc.relation.journalWebOfScienceCategoryMedicine, General & Internal-
dc.subject.keywordPluscarbon 11-
dc.subject.keywordPlusn sec butyl 1 (2 chlorophenyl) n methyl 3 isoquinolinecarboxamide-
dc.subject.keywordPlus(R)-(11C)1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide-
dc.subject.keywordPlusamide-
dc.subject.keywordPlusisoquinoline derivative-
dc.subject.keywordPlusradiopharmaceutical agent-
dc.subject.keywordPlusadult-
dc.subject.keywordPlusArticle-
dc.subject.keywordPlusbasal ganglion-
dc.subject.keywordPluscase control study-
dc.subject.keywordPluscaudate nucleus-
dc.subject.keywordPlusclinical article-
dc.subject.keywordPluscomplex regional pain syndrome-
dc.subject.keywordPluscontrolled study-
dc.subject.keywordPlusfemale-
dc.subject.keywordPlusglobus pallidus-
dc.subject.keywordPlushuman-
dc.subject.keywordPlusmale-
dc.subject.keywordPlusMcGill Pain Questionnaire-
dc.subject.keywordPlusmicroglia-
dc.subject.keywordPlusnervous system inflammation-
dc.subject.keywordPlusnucleus accumbens-
dc.subject.keywordPluspain assessment-
dc.subject.keywordPluspain severity-
dc.subject.keywordPluspilot study-
dc.subject.keywordPluspositron emission tomography-
dc.subject.keywordPluspriority journal-
dc.subject.keywordPlusputamen-
dc.subject.keywordPlusthalamus-
dc.subject.keywordPlusvisual analog scale-
dc.subject.keywordPluscomplex regional pain syndrome-
dc.subject.keywordPlusdiagnostic imaging-
dc.subject.keywordPlusinflammation-
dc.subject.keywordPlusmetabolism-
dc.subject.keywordPlusmiddle aged-
dc.subject.keywordPluspain measurement-
dc.subject.keywordPluspositron emission tomography-
dc.subject.keywordPlusprocedures-
dc.subject.keywordPlusAdult-
dc.subject.keywordPlusAmides-
dc.subject.keywordPlusBasal Ganglia-
dc.subject.keywordPlusCase-Control Studies-
dc.subject.keywordPlusCaudate Nucleus-
dc.subject.keywordPlusComplex Regional Pain Syndromes-
dc.subject.keywordPlusFemale-
dc.subject.keywordPlusGlobus Pallidus-
dc.subject.keywordPlusHumans-
dc.subject.keywordPlusInflammation-
dc.subject.keywordPlusIsoquinolines-
dc.subject.keywordPlusMale-
dc.subject.keywordPlusMiddle Aged-
dc.subject.keywordPlusNucleus Accumbens-
dc.subject.keywordPlusPain Measurement-
dc.subject.keywordPlusPilot Projects-
dc.subject.keywordPlusPositron-Emission Tomography-
dc.subject.keywordPlusPutamen-
dc.subject.keywordPlusRadiopharmaceuticals-
dc.subject.keywordPlusThalamus-
dc.subject.keywordAuthorCentral sensitization-
dc.subject.keywordAuthorComplex regional pain syndrome-
dc.subject.keywordAuthorMicroglia-
dc.subject.keywordAuthorNeuroinflammation-
dc.subject.keywordAuthorPK11195-PET-
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