RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network
DC Field | Value | Language |
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dc.contributor.author | Kim K. | - |
dc.contributor.author | Boo K. | - |
dc.contributor.author | Yu Y.S. | - |
dc.contributor.author | Oh S.K. | - |
dc.contributor.author | Kim H. | - |
dc.contributor.author | Jeon Y. | - |
dc.contributor.author | Bhin J. | - |
dc.contributor.author | Hwang D. | - |
dc.contributor.author | Kim K.I. | - |
dc.contributor.author | Lee J.-S. | - |
dc.contributor.author | Im S.-S. | - |
dc.contributor.author | Yoon S.G. | - |
dc.contributor.author | Kim I.Y. | - |
dc.contributor.author | Seong J.K. | - |
dc.contributor.author | Lee H. | - |
dc.contributor.author | Fang S. | - |
dc.contributor.author | Baek S.H. | - |
dc.date.available | 2020-11-02T10:41:03Z | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5658 | - |
dc.description.abstract | The retinoic acid receptor-related orphan receptor-α (RORα) is an important regulator of various biological processes, including cerebellum development, circadian rhythm and cancer. Here, we show that hepatic RORα controls lipid homeostasis by negatively regulating transcriptional activity of peroxisome proliferators-activated receptor-γ (PPARγ) that mediates hepatic lipid metabolism. Liver-specific Rorα-deficient mice develop hepatic steatosis, obesity and insulin resistance when challenged with a high-fat diet (HFD). Global transcriptome analysis reveals that liver-specific deletion of Rorα leads to the dysregulation of PPARγ signaling and increases hepatic glucose and lipid metabolism. RORα specifically binds and recruits histone deacetylase 3 (HDAC3) to PPARγ target promoters for the transcriptional repression of PPARγ. PPARγ antagonism restores metabolic homeostasis in HFD-fed liver-specific Rorα deficient mice. Our data indicate that RORα has a pivotal role in the regulation of hepatic lipid homeostasis. Therapeutic strategies designed to modulate RORα activity may be beneficial for the treatment of metabolic disorders. © 2017 The Author(s). | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Publishing Group | - |
dc.title | RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1038/s41467-017-00215-1 | - |
dc.identifier.scopusid | 2-s2.0-85026528725 | - |
dc.identifier.bibliographicCitation | Nature Communications, v.8, no.1 | - |
dc.citation.title | Nature Communications | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | glucose | - |
dc.subject.keywordPlus | histone deacetylase 3 | - |
dc.subject.keywordPlus | lipid | - |
dc.subject.keywordPlus | peroxisome proliferator activated receptor gamma | - |
dc.subject.keywordPlus | retinoic acid receptor alpha | - |
dc.subject.keywordPlus | transcriptome | - |
dc.subject.keywordPlus | glucose | - |
dc.subject.keywordPlus | histone deacetylase | - |
dc.subject.keywordPlus | histone deacetylase 3 | - |
dc.subject.keywordPlus | peroxisome proliferator activated receptor gamma | - |
dc.subject.keywordPlus | retinoid related orphan receptor alpha | - |
dc.subject.keywordPlus | Rora protein, mouse | - |
dc.subject.keywordPlus | cancer | - |
dc.subject.keywordPlus | circadian rhythm | - |
dc.subject.keywordPlus | developmental biology | - |
dc.subject.keywordPlus | gene expression | - |
dc.subject.keywordPlus | glucose | - |
dc.subject.keywordPlus | homeostasis | - |
dc.subject.keywordPlus | hormone | - |
dc.subject.keywordPlus | lipid | - |
dc.subject.keywordPlus | metabolism | - |
dc.subject.keywordPlus | obesity | - |
dc.subject.keywordPlus | protein | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | fatty liver | - |
dc.subject.keywordPlus | gene deletion | - |
dc.subject.keywordPlus | gene expression | - |
dc.subject.keywordPlus | genetic transcription | - |
dc.subject.keywordPlus | glucose metabolism | - |
dc.subject.keywordPlus | insulin resistance | - |
dc.subject.keywordPlus | insulin sensitivity | - |
dc.subject.keywordPlus | lipid diet | - |
dc.subject.keywordPlus | lipid homeostasis | - |
dc.subject.keywordPlus | lipid liver level | - |
dc.subject.keywordPlus | lipid metabolism | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | obesity | - |
dc.subject.keywordPlus | promoter region | - |
dc.subject.keywordPlus | protein function | - |
dc.subject.keywordPlus | signal transduction | - |
dc.subject.keywordPlus | transcription regulation | - |
dc.subject.keywordPlus | animal | - |
dc.subject.keywordPlus | antagonists and inhibitors | - |
dc.subject.keywordPlus | gene expression regulation | - |
dc.subject.keywordPlus | gene regulatory network | - |
dc.subject.keywordPlus | genetics | - |
dc.subject.keywordPlus | homeostasis | - |
dc.subject.keywordPlus | lipogenesis | - |
dc.subject.keywordPlus | liver | - |
dc.subject.keywordPlus | metabolism | - |
dc.subject.keywordPlus | Mus | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Diet, High-Fat | - |
dc.subject.keywordPlus | Fatty Liver | - |
dc.subject.keywordPlus | Gene Expression Regulation | - |
dc.subject.keywordPlus | Gene Regulatory Networks | - |
dc.subject.keywordPlus | Glucose | - |
dc.subject.keywordPlus | Histone Deacetylases | - |
dc.subject.keywordPlus | Homeostasis | - |
dc.subject.keywordPlus | Insulin Resistance | - |
dc.subject.keywordPlus | Lipid Metabolism | - |
dc.subject.keywordPlus | Lipogenesis | - |
dc.subject.keywordPlus | Liver | - |
dc.subject.keywordPlus | Mice | - |
dc.subject.keywordPlus | Nuclear Receptor Subfamily 1, Group F, Member 1 | - |
dc.subject.keywordPlus | Obesity | - |
dc.subject.keywordPlus | PPAR gamma | - |
dc.subject.keywordPlus | Promoter Regions, Genetic | - |
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