Prognostic Significance of F-18-FDG Uptake in Hepatocellular Carcinoma Treated with Transarterial Chemoembolization or Concurrent Chemoradiotherapy: A Multicenter Retrospective Cohort Study
DC Field | Value | Language |
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dc.contributor.author | Lee, Jeong Won | - |
dc.contributor.author | Oh, Jin Kyoung | - |
dc.contributor.author | Chung, Yong An | - |
dc.contributor.author | Na, Sae Jung | - |
dc.contributor.author | Hyun, Seung Hyup | - |
dc.contributor.author | Hong, Il Ki | - |
dc.contributor.author | Eo, Jae Seon | - |
dc.contributor.author | Song, Bong-Il | - |
dc.contributor.author | Kim, Tae-sung | - |
dc.contributor.author | Kim, Do Young | - |
dc.contributor.author | Kim, Seung Up | - |
dc.contributor.author | Moon, Dae Hyuk | - |
dc.contributor.author | Lee, Jong Doo | - |
dc.contributor.author | Yun, Mijin | - |
dc.date.available | 2020-11-02T12:42:01Z | - |
dc.date.issued | 2016-04-01 | - |
dc.identifier.issn | 0161-5505 | - |
dc.identifier.issn | 1535-5667 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/6545 | - |
dc.description.abstract | This study aimed to assess the prognostic value of F-18-FDG uptake in hepatocellular carcinoma (HCC) patients who had transarterial chemoembolization (TACE) or concurrent intraarterial chemotherapy with external-beam radiotherapy (CCRT) and to compare the prognosis between patients treated with TACE and those with CCRT according to F-18-FDG uptake. Methods: Two hundred fourteen intermediate-to-advanced-stage HCC patients without extrahepatic metastasis who underwent staging F-18-FDG PET/CT before TACE (153 patients) or CCRT (61 patients) were recruited from 7 hospitals. Progression-free survival (PFS) and overall survival (OS) were compared using an optimal cutoff value for tumor-to-normal liver uptake ratio (TLR). Further, PFS and OS were compared according to treatment modalities (TACE vs. CCRT) using the same TLR cutoff value. Results: On multivariate analysis, age and TLR were independent prognostic factors for PFS (P < 0.050). For OS, Child-Pugh classification and TLR were independent prognostic factors (P < 0.050). When the TLR was greater than 2.0, patients treated with CCRT showed significantly better PFS and OS than those treated with TACE after adjusting for tumor size and number (P = 0.014, for all). In contrast, there was no significant difference in PFS and OS between patients treated with TACE or CCRT when the TLR was 2.0 or less. Conclusion: F-18-FDG uptake was an independent prognostic factor for PFS and OS in HCC patients treated with TACE or CCRT. Especially, in HCCs with high F-18-FDG uptake, patients treated with CCRT showed better survival than those treated with TACE. F-18-FDG PET/CT may help determine the treatment modality for intermediate-to-advanced-stage HCCs. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SOC NUCLEAR MEDICINE INC | - |
dc.title | Prognostic Significance of F-18-FDG Uptake in Hepatocellular Carcinoma Treated with Transarterial Chemoembolization or Concurrent Chemoradiotherapy: A Multicenter Retrospective Cohort Study | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.2967/jnumed.115.167338 | - |
dc.identifier.scopusid | 2-s2.0-84963959073 | - |
dc.identifier.wosid | 000373627800015 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NUCLEAR MEDICINE, v.57, no.4, pp 509 - 516 | - |
dc.citation.title | JOURNAL OF NUCLEAR MEDICINE | - |
dc.citation.volume | 57 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 509 | - |
dc.citation.endPage | 516 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | VEIN TUMOR THROMBOSIS | - |
dc.subject.keywordPlus | F-18-FLUORODEOXYGLUCOSE PET/CT | - |
dc.subject.keywordPlus | RADIATION-THERAPY | - |
dc.subject.keywordPlus | PREDICTIVE-VALUE | - |
dc.subject.keywordPlus | FDG PET/CT | - |
dc.subject.keywordPlus | VOLUME | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | F-18-FDG PET | - |
dc.subject.keywordAuthor | transarterial chemoembolization | - |
dc.subject.keywordAuthor | concurrent chemoradiotherapy | - |
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