BMP-2 induces motility and invasiveness by promoting colon cancer stemness through STAT3 activation
DC Field | Value | Language |
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dc.contributor.author | Kim, Bo Ram | - |
dc.contributor.author | Oh, Sang Cheul | - |
dc.contributor.author | Lee, Dae-Hee | - |
dc.contributor.author | Kim, Jung Lim | - |
dc.contributor.author | Lee, Suk Young | - |
dc.contributor.author | Kang, Myoung Hee | - |
dc.contributor.author | Lee, Sun Il | - |
dc.contributor.author | Kang, Sanghee | - |
dc.contributor.author | Joung, Sung Yup | - |
dc.contributor.author | Min, Byung Wook | - |
dc.date.available | 2020-11-02T14:41:16Z | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 1010-4283 | - |
dc.identifier.issn | 1423-0380 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/7255 | - |
dc.description.abstract | Bone morphogenetic proteins (BMPs) have been involved in metastatic progression and tumorigenesis of many cancer types. However, it remains unclear how BMP-2 contributes to the initiation and development of these cancers. Here, we investigated the role of BMP-2 in colon cancer stem cell (CSC) development from colon cancer cells. We also determined the effects of BMP-2 on CSC development and epithelial-mesenchymal transition (EMT) in human colon cancer cell lines HCT-116 and SW620. We found that BMP-2 enhanced sphere formation of colon cancer cells without serum. Also, BMP-2-induced spheres displayed up-regulation of stemness markers (CD133+ and EpCAM+) and increased drug resistance, hallmarks of CSCs. Importantly, expression of EMT activators p-Smad1/5 and Snail and N-cadherin was increased in the spheres' cells, indicating that BMP-2 signaling might result in CSC self-renewal and EMT. Furthermore, siRNA-mediated knockdown of signal transducer and activator of transcription 3 (STAT3) in HCT-116 cells reversed BMP-2-induced EMT and stem cell formation. Taken together, our results suggest that the BMP-2 induced STAT3-mediated induction of colon cancer cell metastasis requires an EMT and/or changes in CSC markers. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.title | BMP-2 induces motility and invasiveness by promoting colon cancer stemness through STAT3 activation | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1007/s13277-015-3681-y | - |
dc.identifier.scopusid | 2-s2.0-84952873854 | - |
dc.identifier.wosid | 000367329300042 | - |
dc.identifier.bibliographicCitation | TUMOR BIOLOGY, v.36, no.12, pp 9475 - 9486 | - |
dc.citation.title | TUMOR BIOLOGY | - |
dc.citation.volume | 36 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 9475 | - |
dc.citation.endPage | 9486 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | BONE MORPHOGENETIC PROTEIN-2 | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITIONS | - |
dc.subject.keywordPlus | PHOSPHATIDYLINOSITOL 3-KINASE | - |
dc.subject.keywordPlus | CHONDROSARCOMA CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | AKT | - |
dc.subject.keywordPlus | PI3K/AKT | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | MAPK | - |
dc.subject.keywordAuthor | Colon cancer | - |
dc.subject.keywordAuthor | Bone morphogenetic proteins | - |
dc.subject.keywordAuthor | Cancer stem cells | - |
dc.subject.keywordAuthor | Epithelial-mesenchymal transition | - |
dc.subject.keywordAuthor | Signal transducer and activator of transcription 3 | - |
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