Long-Term Clinical Outcomes of Fractional Flow Reserve-Guided Versus Routine Drug-Eluting Stent Implantation in Patients With Intermediate Coronary Stenosis Five-Year Clinical Outcomes of DEFER-DES Trial
DC Field | Value | Language |
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dc.contributor.author | Park, Sang Hyun | - |
dc.contributor.author | Jeon, Ki-Hyun | - |
dc.contributor.author | Lee, Joo Myung | - |
dc.contributor.author | Nam, Chang-Wook | - |
dc.contributor.author | Doh, Joon-Hyung | - |
dc.contributor.author | Lee, Bong-Ki | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.contributor.author | Yoo, Ki-dong | - |
dc.contributor.author | Jung, Kyung Tae | - |
dc.contributor.author | Cho, Young-Seok | - |
dc.contributor.author | Lee, Hae-Young | - |
dc.contributor.author | Youn, Tae-Jin | - |
dc.contributor.author | Chung, Woo-Young | - |
dc.contributor.author | Koo, Bon-Kwon | - |
dc.date.available | 2020-11-02T14:41:46Z | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 1941-7640 | - |
dc.identifier.issn | 1941-7632 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/7314 | - |
dc.description.abstract | Background We aimed to compare the long-term clinical outcomes between fractional flow reserve (FFR)-guided and routine drug-eluting stent (DES) implantation in patients with an intermediate coronary stenosis. Methods and Results A total of 229 patients with an angiographically intermediate coronary stenosis were randomly assigned to FFR-guided or Routine-DES implantation group. For FFR-guided group (n=114), treatment strategy was determined according to the target vessel FFR (FFR<0.75: DES implantation [FFR-DES group]; FFR0.75: deferral of stenting [FFR-Defer group]). Routine-DES group underwent DES implantation without FFR measurement (n=115). The primary end point was the incidence of major adverse cardiac events, a composite of cardiac death, myocardial infarction, and target lesion revascularization. Of lesions assigned to FFR-guided strategy, only one quarter had functional significance (FFR<0.75). At 2-year follow-up, the cumulative incidence of major adverse cardiac events was 7.92.5% in the FFR-guided group and 8.82.7% in Routine-DES group (P=0.80). At 5-year follow-up, the cumulative incidence of major adverse cardiac events was 11.6 +/- 3.0% and 14.2 +/- 3.3% for the FFR-guided group and the Routine-DES group (P=0.55). There was no difference in major adverse cardiac events rates between the 2 groups 5-year follow-up (hazard ratio, 1.25; 95% confidence interval, 0.60-2.60). Conclusions In lesions with angiographically intermediate stenosis, FFR guidance provides a tailored approach, which is at least as good as an angiography-guided routine-DES implantation strategy and avoids unnecessary DES-stenting in a considerable part of the patients. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Long-Term Clinical Outcomes of Fractional Flow Reserve-Guided Versus Routine Drug-Eluting Stent Implantation in Patients With Intermediate Coronary Stenosis Five-Year Clinical Outcomes of DEFER-DES Trial | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1161/CIRCINTERVENTIONS.115.002442 | - |
dc.identifier.scopusid | 2-s2.0-84951112864 | - |
dc.identifier.wosid | 000366753400001 | - |
dc.identifier.bibliographicCitation | CIRCULATION-CARDIOVASCULAR INTERVENTIONS, v.8, no.12 | - |
dc.citation.title | CIRCULATION-CARDIOVASCULAR INTERVENTIONS | - |
dc.citation.volume | 8 | - |
dc.citation.number | 12 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | RANDOMIZED-TRIALS | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | INTERVENTION | - |
dc.subject.keywordPlus | ANGIOPLASTY | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordPlus | ARTERY | - |
dc.subject.keywordPlus | ANGIOGRAPHY | - |
dc.subject.keywordPlus | POLYMER | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | coronary artery disease | - |
dc.subject.keywordAuthor | coronary stenosis | - |
dc.subject.keywordAuthor | drug-eluting stents | - |
dc.subject.keywordAuthor | myocardial fractional flow reserve | - |
dc.subject.keywordAuthor | percutaneous coronary intervention | - |
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