Endogenous Ligand for GPR120, Docosahexaenoic Acid, Exerts Benign Metabolic Effects on the Skeletal Muscles via AMP-activated Protein Kinase Pathway
DC Field | Value | Language |
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dc.contributor.author | Kim, Nami | - |
dc.contributor.author | Lee, Jung Ok | - |
dc.contributor.author | Lee, Hye Jeong | - |
dc.contributor.author | Kim, Hyung Ip | - |
dc.contributor.author | Kim, Joong Kwan | - |
dc.contributor.author | Lee, Yong Woo | - |
dc.contributor.author | Lee, Soo Kyung | - |
dc.contributor.author | Kim, Su Jin | - |
dc.contributor.author | Park, Sun Hwa | - |
dc.contributor.author | Kim, Hyeon Soo | - |
dc.date.available | 2020-11-02T15:23:46Z | - |
dc.date.issued | 2015-08 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.issn | 1083-351X | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/7618 | - |
dc.description.abstract | Docosahexaenoic acid (DHA) is an endogenous ligand of G protein-coupled receptor 120 (GPR120). However, the mechanisms underlying DHA action are poorly understood. In this study, DHA stimulated glucose uptake in the skeletal muscles in an AMP-activated protein kinase (AMPK)-dependent manner. GPR120-mediated increase in intracellular Ca2+ was critical for DHA-mediated AMPK phosphorylation and glucose uptake. In addition, DHA stimulated GLUT4 translocation AMPK-dependently. Inhibition of AMPK and Ca2+/calmodulin-dependent protein kinase kinase blocked DHA-induced glucose uptake. DHA and GW9508, a GPR120 agonist, increased GPR120 expression. DHA-mediated glucose uptake was not observed in GPR120 knockdown conditions. DHA increased AMPK phosphorylation, glucose uptake, and intracellular Ca2+ concentration in primary cultured myoblasts. Taken together, these results indicated that the beneficial metabolic role of DHA was attributed to its ability to regulate glucose via the GPR120-mediated AMPK pathway in the skeletal muscles. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | American Society for Biochemistry and Molecular Biology Inc. | - |
dc.title | Endogenous Ligand for GPR120, Docosahexaenoic Acid, Exerts Benign Metabolic Effects on the Skeletal Muscles via AMP-activated Protein Kinase Pathway | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1074/jbc.M115.657379 | - |
dc.identifier.scopusid | 2-s2.0-84939609969 | - |
dc.identifier.wosid | 000359608900041 | - |
dc.identifier.bibliographicCitation | Journal of Biological Chemistry, v.290, no.33, pp 20438 - 20447 | - |
dc.citation.title | Journal of Biological Chemistry | - |
dc.citation.volume | 290 | - |
dc.citation.number | 33 | - |
dc.citation.startPage | 20438 | - |
dc.citation.endPage | 20447 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | PANCREATIC BETA-CELLS | - |
dc.subject.keywordPlus | CHAIN FATTY-ACIDS | - |
dc.subject.keywordPlus | INSULIN-SECRETION | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | GLUCOSE-TRANSPORT | - |
dc.subject.keywordPlus | COUPLED RECEPTORS | - |
dc.subject.keywordPlus | UPSTREAM KINASE | - |
dc.subject.keywordPlus | CONTRACTION | - |
dc.subject.keywordPlus | GLUT4 | - |
dc.subject.keywordPlus | MICE | - |
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