Detailed Information

Cited 5 time in webofscience Cited 7 time in scopus
Metadata Downloads

Clinical Significance of Hepatitis B Virus Precore and Core Promoter Variants in Korean Patients With Chronic Hepatitis B

Full metadata record
DC Field Value Language
dc.contributor.authorYim, Sun Young-
dc.contributor.authorUm, Soon Ho-
dc.contributor.authorJung, Jin Young-
dc.contributor.authorKim, Tae Hyung-
dc.contributor.authorKim, Jin Dong-
dc.contributor.authorKeum, Bora-
dc.contributor.authorSeo, Yeon Seok-
dc.contributor.authorYim, Hyung Joon-
dc.contributor.authorJeen, Yoon Tae-
dc.contributor.authorLee, Hong Sik-
dc.contributor.authorChun, Hoon Jai-
dc.contributor.authorKim, Chang Duck-
dc.contributor.authorRyu, Ho Sang-
dc.date.available2020-11-02T16:41:58Z-
dc.date.issued2015-01-
dc.identifier.issn0192-0790-
dc.identifier.issn1539-2031-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/8264-
dc.description.abstractBackground/Aim: We aimed to clarify the clinical significance of precore (preC)/core promoter (CP) variants of hepatitis B virus (HBV) in chronic hepatitis B (CHB) patients. Methods: We assessed serum HBeAg, HBV DNA levels, alanine transferase (ALT) levels, and progression of liver fibrosis in 226 Korean CHB patients, presumed to be infected with genotype C HBV, to analyze HBV variants in the preC region (G1896A) and CP regions (A1762T, G1764A). Results: CP and preC variants were more frequently found in HBeAg-negative patients than in HBeAg-positive patients (P < 0.05). HBeAg-positive patients with CP variants had higher ALT levels and more advanced fibrosis scores (all P < 0.01) than those without variants; those with preC variant had lower HBV DNA levels (P = 0.009), with no significant difference in ALT levels and fibrosis scores. However, no significant correlation was found between HBV variants and clinicopathologic findings in HBeAg-negative patients. Furthermore, multivariate analysis revealed that (1) progression of liver fibrosis (>= F2) was associated with older age in both HBeAg-positive and HBeAg-negative patients (P < 0.05) and with CP variants in the HBeAg-positive group (P = 0.007), and (2) HBV DNA levels were positively correlated with ALT levels, irrespective of HBeAg (P < 0.05), whereas they were negatively correlated with the presence of preC variant in the HBeAg-positive group (P = 0.004). Conclusions: In HBeAg-positive CHB patients infected with genotype C HBV, preC variant was associated with enhanced host immune response with lower HBV DNA levels, whereas CP variants were associated with severe liver damage and liver fibrosis progression.-
dc.format.extent8-
dc.language영어-
dc.language.isoENG-
dc.publisherLIPPINCOTT WILLIAMS & WILKINS-
dc.titleClinical Significance of Hepatitis B Virus Precore and Core Promoter Variants in Korean Patients With Chronic Hepatitis B-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.scopusid2-s2.0-84891777889-
dc.identifier.wosid000346149800013-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL GASTROENTEROLOGY, v.49, no.1, pp 61 - 68-
dc.citation.titleJOURNAL OF CLINICAL GASTROENTEROLOGY-
dc.citation.volume49-
dc.citation.number1-
dc.citation.startPage61-
dc.citation.endPage68-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaGastroenterology & Hepatology-
dc.relation.journalWebOfScienceCategoryGastroenterology & Hepatology-
dc.subject.keywordPlusE-ANTIGEN-
dc.subject.keywordPlusVIRAL REPLICATION-
dc.subject.keywordPlusUNITED-STATES-
dc.subject.keywordPlusLIVER-DAMAGE-
dc.subject.keywordPlusMUTATIONS-
dc.subject.keywordPlusGENOTYPES-
dc.subject.keywordPlusDNA-
dc.subject.keywordPlusINFECTION-
dc.subject.keywordPlusREGION-
dc.subject.keywordPlusSEROCONVERSION-
dc.subject.keywordAuthorchronic hepatitis B-
dc.subject.keywordAuthorprecore variant-
dc.subject.keywordAuthorcore promoter variants-
dc.subject.keywordAuthorhepatitis B virus-
dc.subject.keywordAuthorhepatitis B e antigen-
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Jeen, Yoon Tae photo

Jeen, Yoon Tae
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE