Predictive value of urinary and serum biomarkers in young children with febrile urinary tract infections
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yim, Hyung Eun | - |
dc.contributor.author | Yim, Hyungshin | - |
dc.contributor.author | Bae, Eun Soo | - |
dc.contributor.author | Woo, Sang Uk | - |
dc.contributor.author | Yoo, Kee Hwan | - |
dc.date.available | 2020-11-02T17:42:33Z | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 0931-041X | - |
dc.identifier.issn | 1432-198X | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/8776 | - |
dc.description.abstract | Background Early predictive biomarkers for the diagnosis and management of febrile urinary tract infections (UTIs) can be valuable diagnostic tools in children. Methods The study cohort comprised 73 pediatric patients with febrile UTIs [46 with acute pyelonephritis (APN) and 27 with lower UTIs] and 56 healthy children. Urine neutrophil gelatinase-associated lipocalin (uNGAL) and kidney injury molecule-1 (uKIM-1) levels and serum cystatin C (sCysC) levels were measured. Results The uNGAL/creatinine (Cr) and uKIM-1/Cr levels were higher in the UTI group than in the controls (P < 0.05). uNGAL/Cr and sCysC levels were higher in patients with APN than in those with lower UTIs (P < 0.05). uNGAL/Cr levels in both the APN and UTI groups decreased following the administration of antibiotics compared to those before treatment (P < 0.05). The uNGAL/Cr level was correlated with serum levels of white blood cells, C-reactive protein, CysC and with uKIM-1/Cr (P < 0.05). uKIM-1/Cr was also correlated with sCysC (P < 0.05). Receiver operating curve analyses showed good diagnostic profiles of uNGAL/Cr and uKIM-1/Cr for identifying UTIs [area under the curve (AUC) 0.9 and 0.66, respectively) and of uNGAL/Cr and sCysC for predicting APN (AUC 0.78 and 0.72, respectively). Conclusions Our results suggest that uNGAL, uKIM-1 and sCysC levels may be useful for predicting and managing febrile UTIs in children. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Springer Verlag | - |
dc.title | Predictive value of urinary and serum biomarkers in young children with febrile urinary tract infections | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1007/s00467-014-2845-0 | - |
dc.identifier.scopusid | 2-s2.0-84930701187 | - |
dc.identifier.wosid | 000342457700017 | - |
dc.identifier.bibliographicCitation | Pediatric Nephrology, v.29, no.11, pp 2181 - 2189 | - |
dc.citation.title | Pediatric Nephrology | - |
dc.citation.volume | 29 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2181 | - |
dc.citation.endPage | 2189 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | GELATINASE-ASSOCIATED LIPOCALIN | - |
dc.subject.keywordPlus | ACUTE KIDNEY INJURY | - |
dc.subject.keywordPlus | CYSTATIN-C | - |
dc.subject.keywordPlus | MOLECULE-1 KIM-1 | - |
dc.subject.keywordPlus | ACUTE PYELONEPHRITIS | - |
dc.subject.keywordPlus | EARLY-DIAGNOSIS | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | INFANTS | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordAuthor | Acute kidney injury | - |
dc.subject.keywordAuthor | Bacterial infections | - |
dc.subject.keywordAuthor | Biomarkers | - |
dc.subject.keywordAuthor | Child | - |
dc.subject.keywordAuthor | Pyelonephritis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.