Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women
DC Field | Value | Language |
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dc.contributor.author | Wong, Jason Y. Y. | - |
dc.contributor.author | Zhang, Han | - |
dc.contributor.author | Hsiung, Chao A. | - |
dc.contributor.author | Shiraishi, Kouya | - |
dc.contributor.author | Yu, Kai | - |
dc.contributor.author | Matsuo, Keitaro | - |
dc.contributor.author | Wong, Maria Pik | - |
dc.contributor.author | Hong, Yun-Chul | - |
dc.contributor.author | Wang, Jiucun | - |
dc.contributor.author | Seow, Wei Jie | - |
dc.contributor.author | Wang, Zhaoming | - |
dc.contributor.author | Song, Minsun | - |
dc.contributor.author | Kim, Hee Nam | - |
dc.contributor.author | Chang, I-Shou | - |
dc.contributor.author | Chatterjee, Nilanjan | - |
dc.contributor.author | Hu, Wei | - |
dc.contributor.author | Wu, Chen | - |
dc.contributor.author | Mitsudomi, Tetsuya | - |
dc.contributor.author | Zheng, Wei | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Seow, Adeline | - |
dc.contributor.author | Caporaso, Neil E. | - |
dc.contributor.author | Shin, Min-Ho | - |
dc.contributor.author | Chung, Lap Ping | - |
dc.contributor.author | An, She-Juan | - |
dc.contributor.author | Wang, Ping | - |
dc.contributor.author | Yang, Yang | - |
dc.contributor.author | Zheng, Hong | - |
dc.contributor.author | Yatabe, Yasushi | - |
dc.contributor.author | Zhang, Xu-Chao | - |
dc.contributor.author | Kim, Young Tae | - |
dc.contributor.author | Cai, Qiuyin | - |
dc.contributor.author | Yin, Zhihua | - |
dc.contributor.author | Kim, Young-Chul | - |
dc.contributor.author | Bassig, Bryan A. | - |
dc.contributor.author | Chang, Jiang | - |
dc.contributor.author | Ho, James Chung N. | - |
dc.contributor.author | Ji, Bu-Tian | - |
dc.contributor.author | Daigo, Yataro | - |
dc.contributor.author | Ito, Hidemi | - |
dc.contributor.author | Momozawa, Yukihide | - |
dc.contributor.author | Ashikawa, Kyota | - |
dc.contributor.author | Kamatani, Yoichiro | - |
dc.contributor.author | Honda, Takayuki | - |
dc.contributor.author | Hosgood, H. Dean | - |
dc.contributor.author | Sakamoto, Hiromi | - |
dc.contributor.author | Kunitoh, Hideo | - |
dc.contributor.author | Tsuta, Koji | - |
dc.contributor.author | Watanabe, Shun-Ichi | - |
dc.contributor.author | Kubo, Michiaki | - |
dc.contributor.author | Miyagi, Yohei | - |
dc.contributor.author | Nakayama, Haruhiko | - |
dc.contributor.author | Matsumoto, Shingo | - |
dc.contributor.author | Tsuboi, Masahiro | - |
dc.contributor.author | Goto, Koichi | - |
dc.contributor.author | Shi, Jianxin | - |
dc.contributor.author | Song, Lei | - |
dc.contributor.author | Hua, Xing | - |
dc.contributor.author | Takahashi, Atsushi | - |
dc.contributor.author | Goto, Akiteru | - |
dc.contributor.author | Minamiya, Yoshihiro | - |
dc.contributor.author | Shimizu, Kimihiro | - |
dc.contributor.author | Tanaka, Kazumi | - |
dc.contributor.author | Wei, Fusheng | - |
dc.contributor.author | Matsuda, Fumihiko | - |
dc.contributor.author | Su, Jian | - |
dc.contributor.author | Kim, Yeul Hong | - |
dc.contributor.author | Oh, In-Jae | - |
dc.contributor.author | Song, Fengju | - |
dc.contributor.author | Su, Wu-Chou | - |
dc.contributor.author | Chen, Yu-Min | - |
dc.contributor.author | Chang, Gee-Chen | - |
dc.contributor.author | Chen, Kuan-Yu | - |
dc.contributor.author | Huang, Ming-Shyan | - |
dc.contributor.author | Chien, Li-Hsin | - |
dc.contributor.author | Xiang, Yong-Bing | - |
dc.contributor.author | Park, Jae Yong | - |
dc.contributor.author | Kweon, Sun-Seog | - |
dc.contributor.author | Chen, Chien-Jen | - |
dc.contributor.author | Lee, Kyoung-Mu | - |
dc.contributor.author | Blechter, Batel | - |
dc.contributor.author | Li, Haixin | - |
dc.contributor.author | Gao, Yu-Tang | - |
dc.contributor.author | Qian, Biyun | - |
dc.contributor.author | Lu, Daru | - |
dc.contributor.author | Liu, Jianjun | - |
dc.contributor.author | Jeon, Hyo-Sung | - |
dc.contributor.author | Hsiao, Chin-Fu | - |
dc.contributor.author | Sung, Jae Sook | - |
dc.contributor.author | Tsai, Ying-Huang | - |
dc.contributor.author | Jung, Yoo Jin | - |
dc.contributor.author | Guo, Huan | - |
dc.contributor.author | Hu, Zhibin | - |
dc.contributor.author | Wang, Wen-Chang | - |
dc.contributor.author | Chung, Charles C. | - |
dc.contributor.author | Burdett, Laurie | - |
dc.contributor.author | Yeager, Meredith | - |
dc.contributor.author | Hutchinson, Amy | - |
dc.contributor.author | Berndt, Sonja, I | - |
dc.contributor.author | Wu, Wei | - |
dc.contributor.author | Pang, Herbert | - |
dc.contributor.author | Li, Yuqing | - |
dc.contributor.author | Choi, Jin Eun | - |
dc.contributor.author | Park, Kyong Hwa | - |
dc.contributor.author | Sung, Sook Whan | - |
dc.contributor.author | Liu, Li | - |
dc.contributor.author | Kang, C. H. | - |
dc.contributor.author | Zhu, Meng | - |
dc.contributor.author | Chen, Chung-Hsing | - |
dc.contributor.author | Yang, Tsung-Ying | - |
dc.contributor.author | Xu, Jun | - |
dc.contributor.author | Guan, Peng | - |
dc.contributor.author | Tan, Wen | - |
dc.contributor.author | Wang, Chih-Liang | - |
dc.contributor.author | Hsin, Michael | - |
dc.contributor.author | Sit, Ko-Yung | - |
dc.contributor.author | Ho, James | - |
dc.contributor.author | Chen, Ying | - |
dc.contributor.author | Choi, Yi Young | - |
dc.contributor.author | Hung, Jen-Yu | - |
dc.contributor.author | Kim, Jun Suk | - |
dc.contributor.author | Yoon, Ho Il | - |
dc.contributor.author | Lin, Chien-Chung | - |
dc.contributor.author | Park, In Kyu | - |
dc.contributor.author | Xu, Ping | - |
dc.contributor.author | Wang, Yuzhuo | - |
dc.contributor.author | He, Qincheng | - |
dc.contributor.author | Perng, Reury-Perng | - |
dc.contributor.author | Chen, Chih-Yi | - |
dc.contributor.author | Vermeulen, Roel | - |
dc.contributor.author | Wu, Junjie | - |
dc.contributor.author | Lim, Wei-Yen | - |
dc.contributor.author | Chen, Kun-Chieh | - |
dc.contributor.author | Li, Yao-Jen | - |
dc.contributor.author | Li, Jihua | - |
dc.contributor.author | Chen, Hongyan | - |
dc.contributor.author | Yu, Chong-Jen | - |
dc.contributor.author | Jin, Li | - |
dc.contributor.author | Chen, Tzu-Yu | - |
dc.contributor.author | Jiang, Shih-Sheng | - |
dc.contributor.author | Liu, Jie | - |
dc.contributor.author | Yamaji, Taiki | - |
dc.contributor.author | Hicks, Belynda | - |
dc.contributor.author | Wyatt, Kathleen | - |
dc.contributor.author | Li, Shengchao A. | - |
dc.contributor.author | Dai, Juncheng | - |
dc.contributor.author | Ma, Hongxia | - |
dc.contributor.author | Jin, Guangfu | - |
dc.contributor.author | Song, Bao | - |
dc.contributor.author | Wang, Zhehai | - |
dc.contributor.author | Cheng, Sensen | - |
dc.contributor.author | Li, Xuelian | - |
dc.contributor.author | Ren, Yangwu | - |
dc.contributor.author | Cui, Ping | - |
dc.contributor.author | Iwasaki, Motoki | - |
dc.contributor.author | Shimazu, Taichi | - |
dc.contributor.author | Tsugane, Shoichiro | - |
dc.contributor.author | Zhu, Junjie | - |
dc.contributor.author | Yang, Kaiyun | - |
dc.contributor.author | Jiang, Gening | - |
dc.contributor.author | Fei, Ke | - |
dc.contributor.author | Wu, Guoping | - |
dc.contributor.author | Lin, Hsien-Chin | - |
dc.contributor.author | Chen, Hui-Ling | - |
dc.contributor.author | Fang, Yao-Huei | - |
dc.contributor.author | Tsai, Fang-Yu | - |
dc.contributor.author | Hsieh, Wan-Shan | - |
dc.contributor.author | Yu, Jinming | - |
dc.contributor.author | Stevens, Victoria L. | - |
dc.contributor.author | Laird-Offringa, Ite A. | - |
dc.contributor.author | Marconett, Crystal N. | - |
dc.contributor.author | Rieswijk, Linda | - |
dc.contributor.author | Chao, Ann | - |
dc.contributor.author | Yang, Pan-Chyr | - |
dc.contributor.author | Shu, Xiao-Ou | - |
dc.contributor.author | Wu, Tangchun | - |
dc.contributor.author | Wu, Y. L. | - |
dc.contributor.author | Lin, Dongxin | - |
dc.contributor.author | Chen, Kexin | - |
dc.contributor.author | Zhou, Baosen | - |
dc.contributor.author | Huang, Yun-Chao | - |
dc.contributor.author | Kohno, Takashi | - |
dc.contributor.author | Shen, Hongbing | - |
dc.contributor.author | Chanock, Stephen J. | - |
dc.contributor.author | Rothman, Nathaniel | - |
dc.contributor.author | Lan, Qing | - |
dc.date.available | 2020-11-02T05:57:39Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 0888-7543 | - |
dc.identifier.issn | 1089-8646 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/945 | - |
dc.description.abstract | We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.ygeno.2019.07.008 | - |
dc.identifier.scopusid | 2-s2.0-85068966697 | - |
dc.identifier.wosid | 000514071600020 | - |
dc.identifier.bibliographicCitation | Genomics, v.112, no.2, pp 1223 - 1232 | - |
dc.citation.title | Genomics | - |
dc.citation.volume | 112 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 1223 | - |
dc.citation.endPage | 1232 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | CANCER SUSCEPTIBILITY LOCI | - |
dc.subject.keywordPlus | PULMONARY TUBERCULOSIS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | VARIANTS | - |
dc.subject.keywordPlus | SMOKERS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | MEN | - |
dc.subject.keywordAuthor | Tuberculosis | - |
dc.subject.keywordAuthor | Lung cancer | - |
dc.subject.keywordAuthor | Lung adenocarcinoma | - |
dc.subject.keywordAuthor | Mendelian randomization | - |
dc.subject.keywordAuthor | Pathway analysis | - |
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