Clinical significance of primary tumor resection in colorectal cancer patients with synchronous unresectable metastasis
DC Field | Value | Language |
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dc.contributor.author | Kim M.S. | - |
dc.contributor.author | Chung M. | - |
dc.contributor.author | Ahn J.B. | - |
dc.contributor.author | Kim C.W. | - |
dc.contributor.author | Cho M.S. | - |
dc.contributor.author | Shin S.J. | - |
dc.contributor.author | Baek S.J. | - |
dc.contributor.author | Hur H. | - |
dc.contributor.author | Min B.S. | - |
dc.contributor.author | Baik S.H. | - |
dc.contributor.author | Kim N.K. | - |
dc.date.available | 2020-11-02T19:43:57Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.issn | 1096-9098 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/9963 | - |
dc.description.abstract | Background The aim of this study was to compare the outcomes in colorectal cancer (CRC) patients with synchronous unresectable metastases who received either primary tumor resection (PTR) or chemotherapy as the first treatment and to investigate the clinical course of asymptomatic patients who received chemotherapy as the first treatment. Methods We retrospectively analyzed 324 CRC patients with synchronous unresectable metastases. Overall survival (OS) was analyzed for the two groups (upfront PTR group [n = 72] vs. upfront chemotherapy group [n = 252]). Surgical morbidity and mortality were recorded. In the asymptomatic patients who received upfront chemotherapy, the incidences of primary tumor-related complications were analyzed. Results In patients who underwent PTR as the first treatment, the median OS period was superior to those who received upfront chemotherapy (17.2 vs. 13.6 months, P = 0.002). In the PTR group, surgical morbidity and mortality were 11.6% and 1.9%, respectively. Of the 252 asymptomatic patients, the incidence of primary tumor-related complications was 35%. Emergent surgery was ultimately done in 14% of the 252 patients. Conclusion CRC patients with synchronous unresectable metastases who underwent PTR followed by chemotherapy had significantly longer survival times compared to patients who received chemotherapy as the first treatment. © 2014 Wiley Periodicals, Inc. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley and Sons Inc. | - |
dc.title | Clinical significance of primary tumor resection in colorectal cancer patients with synchronous unresectable metastasis | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/jso.23607 | - |
dc.identifier.scopusid | 2-s2.0-84904036460 | - |
dc.identifier.bibliographicCitation | Journal of Surgical Oncology, v.110, no.2, pp 214 - 221 | - |
dc.citation.title | Journal of Surgical Oncology | - |
dc.citation.volume | 110 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 214 | - |
dc.citation.endPage | 221 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | capecitabine | - |
dc.subject.keywordPlus | fluorouracil | - |
dc.subject.keywordPlus | folinic acid | - |
dc.subject.keywordPlus | irinotecan | - |
dc.subject.keywordPlus | oxaliplatin | - |
dc.subject.keywordPlus | abdominal abscess | - |
dc.subject.keywordPlus | adrenal metastasis | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | anastomosis leakage | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | bone metastasis | - |
dc.subject.keywordPlus | brain metastasis | - |
dc.subject.keywordPlus | cancer chemotherapy | - |
dc.subject.keywordPlus | cancer patient | - |
dc.subject.keywordPlus | cancer surgery | - |
dc.subject.keywordPlus | cancer survival | - |
dc.subject.keywordPlus | colorectal cancer | - |
dc.subject.keywordPlus | distant metastasis | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | ileus | - |
dc.subject.keywordPlus | intestine obstruction | - |
dc.subject.keywordPlus | liver metastasis | - |
dc.subject.keywordPlus | lung lobectomy | - |
dc.subject.keywordPlus | lung metastasis | - |
dc.subject.keywordPlus | lymph node metastasis | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mediastinum metastasis | - |
dc.subject.keywordPlus | metastasis | - |
dc.subject.keywordPlus | overall survival | - |
dc.subject.keywordPlus | paraaortic lymph node | - |
dc.subject.keywordPlus | peritoneum metastasis | - |
dc.subject.keywordPlus | postoperative complication | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | retrospective study | - |
dc.subject.keywordPlus | sepsis | - |
dc.subject.keywordPlus | small intestine cancer | - |
dc.subject.keywordPlus | small intestine metastasis | - |
dc.subject.keywordPlus | surgical infection | - |
dc.subject.keywordPlus | chemotherapy | - |
dc.subject.keywordPlus | colorectal neoplasm | - |
dc.subject.keywordPlus | primary tumor resection | - |
dc.subject.keywordPlus | synchronous unresectable metastasis | - |
dc.subject.keywordPlus | Adult | - |
dc.subject.keywordPlus | Aged | - |
dc.subject.keywordPlus | Antineoplastic Agents | - |
dc.subject.keywordPlus | Antineoplastic Combined Chemotherapy Protocols | - |
dc.subject.keywordPlus | Asymptomatic Diseases | - |
dc.subject.keywordPlus | Camptothecin | - |
dc.subject.keywordPlus | Chemotherapy, Adjuvant | - |
dc.subject.keywordPlus | Colectomy | - |
dc.subject.keywordPlus | Colorectal Neoplasms | - |
dc.subject.keywordPlus | Deoxycytidine | - |
dc.subject.keywordPlus | Drug Administration Schedule | - |
dc.subject.keywordPlus | Female | - |
dc.subject.keywordPlus | Fluorouracil | - |
dc.subject.keywordPlus | Follow-Up Studies | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Kaplan-Meier Estimate | - |
dc.subject.keywordPlus | Leucovorin | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Middle Aged | - |
dc.subject.keywordPlus | Neoplasm Metastasis | - |
dc.subject.keywordPlus | Organoplatinum Compounds | - |
dc.subject.keywordPlus | Palliative Care | - |
dc.subject.keywordPlus | Rectum | - |
dc.subject.keywordPlus | Retrospective Studies | - |
dc.subject.keywordPlus | Survival Rate | - |
dc.subject.keywordPlus | Treatment Outcome | - |
dc.subject.keywordAuthor | chemotherapy | - |
dc.subject.keywordAuthor | colorectal neoplasm | - |
dc.subject.keywordAuthor | primary tumor resection | - |
dc.subject.keywordAuthor | synchronous unresectable metastasis | - |
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