Revisiting glomerular hyperfiltration and examining the concept of high dietary protein-related nephropathy in athletes and bodybuilders
DC Field | Value | Language |
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dc.contributor.author | Cho, Eunjung | - |
dc.contributor.author | Choi, Soo Jeong | - |
dc.contributor.author | Kang, Duk-Hee | - |
dc.contributor.author | Kalantar-Zadeh, Kamyar | - |
dc.contributor.author | Ko, Gang-Jee | - |
dc.date.accessioned | 2022-03-15T00:40:18Z | - |
dc.date.available | 2022-03-15T00:40:18Z | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 1062-4821 | - |
dc.identifier.issn | 1473-6543 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/55401 | - |
dc.description.abstract | Purpose of review High-protein diets (HPDs) are popular but their consequences for kidney health, especially among athletes and bodybuilders who typically maintain a high protein intake for a long time, have not been investigated. This review focused on recent studies of the association of HPD with long-term kidney health and the concept of high dietary protein-related nephropathy. Recent findings Several long-term observational studies including large populations have reinforced the notion that HPDs are associated with a rapid decline of kidney function. An increase in renal blood flow and glomerular hyperfiltration caused by vasodilation, and increased levels of endocrine and paracrine factors (glucagon, IGF-1, prostanoids, and nitric oxide), facilitates the excretion of protein-derived nitrogenous waste. Inhibition of tubule-glomerular feedback and increased proximal tubular Na+ reabsorption after a HPD augment glomerular hyperfiltration and may trigger synthesis of proinflammatory cytokines and receptor for advanced glycation end-products (RAGE). Focal segmental glomerulosclerosis reported in association with anabolic steroid may indeed be a HPD nephropathy given that HPD results in progressive glomerulosclerosis, especially in remnant glomeruli or in diabetic kidney disease but can happen in any high-risk situation, such as solitary kidney and polycystic kidneys. Summary HPD among athletes and bodybuilders in an extreme way across a long-term period may pose a risk to renal health including high incidence of HPD nephropathy. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Lippincott Williams & Wilkins Ltd. | - |
dc.title | Revisiting glomerular hyperfiltration and examining the concept of high dietary protein-related nephropathy in athletes and bodybuilders | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1097/MNH.0000000000000755 | - |
dc.identifier.scopusid | 2-s2.0-85122371801 | - |
dc.identifier.wosid | 000753961800004 | - |
dc.identifier.bibliographicCitation | Current Opinion in Nephrology and Hypertension, v.31, no.1, pp 18 - 25 | - |
dc.citation.title | Current Opinion in Nephrology and Hypertension | - |
dc.citation.volume | 31 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 18 | - |
dc.citation.endPage | 25 | - |
dc.type.docType | Review | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | KIDNEY-DISEASE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | SCLEROSIS | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordAuthor | anabolic steroid nephropathy | - |
dc.subject.keywordAuthor | glomerular hyperfiltration | - |
dc.subject.keywordAuthor | high protein-induced nephropathy | - |
dc.subject.keywordAuthor | kidney health | - |
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