Target Low-Density Lipoprotein-Cholesterol and Secondary Prevention for Patients with Acute Myocardial Infarction: A Korean Nationwide Cohort Study
DC Field | Value | Language |
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dc.contributor.author | Kim, Ju Hyeon | - |
dc.contributor.author | Cha, Jung-Joon | - |
dc.contributor.author | Lim, Subin | - |
dc.contributor.author | An, Jungseok | - |
dc.contributor.author | Kim, Mi-Na | - |
dc.contributor.author | Hong, Soon Jun | - |
dc.contributor.author | Joo, Hyung Joon | - |
dc.contributor.author | Park, Jae Hyoung | - |
dc.contributor.author | Yu, Cheol Woong | - |
dc.contributor.author | Lim, Do-Sun | - |
dc.contributor.author | Byeon, Kyeongmin | - |
dc.contributor.author | Kim, Sang-Wook | - |
dc.contributor.author | Shin, Eun-Seok | - |
dc.contributor.author | Cha, Kwang Soo | - |
dc.contributor.author | Chae, Jei Keon | - |
dc.contributor.author | Ahn, Youngkeun | - |
dc.contributor.author | Jeong, Myung Ho | - |
dc.contributor.author | Ahn, Tae Hoon | - |
dc.date.accessioned | 2022-05-31T00:40:19Z | - |
dc.date.available | 2022-05-31T00:40:19Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/60935 | - |
dc.description.abstract | Although lowering low-density lipoprotein cholesterol (LDL-C) levels following acute myocardial infarction (MI) is the cornerstone of secondary prevention, the attainment of recommended LDL-C goals remains suboptimal in real-world practice. We sought to investigate recurrent adverse events in post-MI patients. From the Korea Acute Myocardial Infarction-National Institutes of Health registry, a total of 5049 patients with both measurements of plasma LDL-C levels at index admission and at the one-year follow-up visit were identified. Patients who achieved an LDL-C reduction >= 50% from the index MI and an LDL-C level <= 70 mg/dL at follow-up were classified as target LDL-C achievers. The primary endpoint was a two-year major adverse cardiac and cerebrovascular event (MACCE), including cardiovascular mortality, recurrent MI, and ischemic stroke. Among the 5049 patients, 1114 (22.1%) patients achieved the target LDL-C level. During a median follow-up of 2.1 years, target LDL-C achievers showed a significantly lower incidence (2.2% vs. 3.5%, log-rank p = 0.022) and a reduced adjusted hazard of MACCE (0.63; p = 0.041). In patients with acute MI, achieving a target LDL-C level was associated with a lower incidence and a reduced hazard of recurrent clinical events. These results highlight the need to improve current practices for managing LDL-C levels in real-world settings. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | Target Low-Density Lipoprotein-Cholesterol and Secondary Prevention for Patients with Acute Myocardial Infarction: A Korean Nationwide Cohort Study | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/jcm11092650 | - |
dc.identifier.scopusid | 2-s2.0-85129478552 | - |
dc.identifier.wosid | 000794676600001 | - |
dc.identifier.bibliographicCitation | Journal of Clinical Medicine, v.11, no.9 | - |
dc.citation.title | Journal of Clinical Medicine | - |
dc.citation.volume | 11 | - |
dc.citation.number | 9 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | ACUTE CORONARY SYNDROMES | - |
dc.subject.keywordPlus | LOWERING THERAPY | - |
dc.subject.keywordPlus | INDIVIDUAL DATA | - |
dc.subject.keywordPlus | INTERVENTIONS | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | REDUCTION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | myocardial infarction | - |
dc.subject.keywordAuthor | low-density lipoprotein cholesterol | - |
dc.subject.keywordAuthor | statin | - |
dc.subject.keywordAuthor | secondary prevention | - |
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