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Cited 4 time in webofscience Cited 3 time in scopus
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Altered TIMP-3 Levels in the Cerebrospinal Fluid and Plasma of Patients with Alzheimer's Disease

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dc.contributor.authorPark, Jung Hyun-
dc.contributor.authorCho, Sun-Jung-
dc.contributor.authorJo, Chulman-
dc.contributor.authorPark, Moon Ho-
dc.contributor.authorHan, Changsu-
dc.contributor.authorKim, Eun-Joo-
dc.contributor.authorHuh, Gi Yeong-
dc.contributor.authorKoh, Young Ho-
dc.date.accessioned2022-06-20T02:40:19Z-
dc.date.available2022-06-20T02:40:19Z-
dc.date.issued2022-05-
dc.identifier.issn2075-4426-
dc.identifier.issn2075-4426-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61047-
dc.description.abstractTissue inhibitor of metalloproteinase-3 (TIMP-3) is a component of the extracellular environment and is suggested to play an indirect role in regulating A beta production and the pathophysiology of A beta deposition in brains. However, studies on the amount of TIMP-3 in bodily fluids of Alzheimer's disease (AD) patients have not been conducted. Here, we investigated the relationship between fluid TIMP-3 levels and AD pathology. We first showed that the fluid levels of TIMP-3 were lower in AD dementia patients compared with in non-AD patients. ELISA results revealed that plasma levels of TIMP-3 in 65 patients with AD were significantly lower than those in 115 healthy control subjects and 71 mild cognitive impairment (MCI) subjects. Furthermore, we found that cerebrospinal fluid (CSF) level of TIMP-3 was decreased in AD compared with that in healthy control. These data suggest that fluid TIMP-3 levels negatively correlated with progress of cognitive decline. Collectively, our study suggests that alterations of fluid TIMP-3 levels might be associated with AD pathology.-
dc.language영어-
dc.language.isoENG-
dc.publisherMDPI AG-
dc.titleAltered TIMP-3 Levels in the Cerebrospinal Fluid and Plasma of Patients with Alzheimer's Disease-
dc.typeArticle-
dc.publisher.location스위스-
dc.identifier.doi10.3390/jpm12050827-
dc.identifier.scopusid2-s2.0-85130865100-
dc.identifier.wosid000804350600001-
dc.identifier.bibliographicCitationJournal of Personalized Medicine, v.12, no.5-
dc.citation.titleJournal of Personalized Medicine-
dc.citation.volume12-
dc.citation.number5-
dc.type.docTypeArticle-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaHealth Care Sciences & Services-
dc.relation.journalResearchAreaGeneral & Internal Medicine-
dc.relation.journalWebOfScienceCategoryHealth Care Sciences & Services-
dc.relation.journalWebOfScienceCategoryMedicine, General & Internal-
dc.subject.keywordPlusMILD COGNITIVE IMPAIRMENT-
dc.subject.keywordPlusCEREBRAL AMYLOID ANGIOPATHY-
dc.subject.keywordPlusMATRIX METALLOPROTEINASES-
dc.subject.keywordPlusTISSUE INHIBITOR-
dc.subject.keywordPlusASSOCIATION WORKGROUPS-
dc.subject.keywordPlusDIAGNOSTIC GUIDELINES-
dc.subject.keywordPlusNATIONAL INSTITUTE-
dc.subject.keywordPlusCONVERTING-ENZYME-
dc.subject.keywordPlusMATRIX-METALLOPROTEINASE-9-
dc.subject.keywordPlusBIOMARKER-
dc.subject.keywordAuthorTIMP-3-
dc.subject.keywordAuthorCSF-
dc.subject.keywordAuthorPlasma-
dc.subject.keywordAuthorAlzheimer's disease-
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Ansan Hospital (Department of Neurology, Ansan Hospital)
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