Phylogenetic analysis of human parainfluenza type 3 virus strains responsible for the outbreak during the COVID-19 pandemic in Seoul, South Korea
DC Field | Value | Language |
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dc.contributor.author | Kim, Ha Nui | - |
dc.contributor.author | Yoon, Soo-Young | - |
dc.contributor.author | Lim, Chae Seung | - |
dc.contributor.author | Lee, Chang Kyu | - |
dc.contributor.author | Yoon, Jung | - |
dc.date.accessioned | 2022-07-04T01:40:15Z | - |
dc.date.available | 2022-07-04T01:40:15Z | - |
dc.date.issued | 2022-08 | - |
dc.identifier.issn | 1386-6532 | - |
dc.identifier.issn | 1873-5967 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61127 | - |
dc.description.abstract | Background Human parainfluenza virus 3 (HPIV3) is a major respiratory pathogen that causes acute respiratory infections in infants and children. Since September 2021, an out-of-season HPIV3 rebound has been noted in Korea. The objective of this study was to analyze the molecular characteristics of the HPIV3 strains responsible for the outbreak in Seoul, South Korea. Methods A total of 61 HPIV3-positive nasopharyngeal swab specimens were collected between October and November 2021. Using 33 HPIV3-positive specimens, partial nucleotide sequences of the HPIV3 hemagglutinin-neuraminidase (HN) gene were aligned with previously published HN gene sequences for phylogenetic and genetic distance (p-distance) analyses. Results Phylogenetic tree revealed that all Seoul HPIV3 strains grouped within the phylogenetic subcluster C3. However, these strains formed a unique cluster that branched separately from the C3a lineage. This cluster showed 99% bootstrap support with a p-distance < 0.001. Genetic distances within the other C3 lineages ranged from 0.013 (C3a) to 0.023 (C3c). Deduced amino acid sequences of the HN gene revealed four protein substitutions in Seoul HPIV3 strains that have rarely been observed in other reference strains: A22T, K31N, G387S, and E514K. Conclusions Phylogenetic analysis of Seoul HPIV3 strains revealed that the strain belonged to a separate cluster within subcluster C3. Genetic distances among strains within subcluster C3 suggest the emergence of a new genetic lineage. The emergence of a new genetic lineage could pose a potential risk of a new epidemic. Further monitoring of the circulating HPIV3 strains is needed to understand the importance of newly discovered mutations. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Phylogenetic analysis of human parainfluenza type 3 virus strains responsible for the outbreak during the COVID-19 pandemic in Seoul, South Korea | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.jcv.2022.105213 | - |
dc.identifier.scopusid | 2-s2.0-85132549027 | - |
dc.identifier.wosid | 000814698100003 | - |
dc.identifier.bibliographicCitation | Journal of Clinical Virology, v.153 | - |
dc.citation.title | Journal of Clinical Virology | - |
dc.citation.volume | 153 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordPlus | HEMAGGLUTININ-NEURAMINIDASE GENE | - |
dc.subject.keywordAuthor | Human parainfluenza virus 3 | - |
dc.subject.keywordAuthor | Phylogenetic analysis | - |
dc.subject.keywordAuthor | Emerging lineages | - |
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