Non-Renal Risk Factors for Chronic Kidney Disease in Liver Recipients with Functionally Intact Kidneys at 1 Month
DC Field | Value | Language |
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dc.contributor.author | Kim, Deok-Gie | - |
dc.contributor.author | Hwang, Shin | - |
dc.contributor.author | Kim, Jong Man | - |
dc.contributor.author | Ryu, Je Ho | - |
dc.contributor.author | You, Young Kyoung | - |
dc.contributor.author | Choi, Donglak | - |
dc.contributor.author | Kim, Bong-Wan | - |
dc.contributor.author | Kim, Dong-Sik | - |
dc.contributor.author | Nah, Yang Won | - |
dc.contributor.author | Kim, Tae-Seok | - |
dc.contributor.author | Cho, Jai Young | - |
dc.contributor.author | Hong, Geun | - |
dc.contributor.author | Yang, Jae Do | - |
dc.contributor.author | Han, Jaryung | - |
dc.contributor.author | Suh, Suk-Won | - |
dc.contributor.author | Kim, Kwan Woo | - |
dc.contributor.author | Jung, Yun Kyung | - |
dc.contributor.author | Moon, Ju Ik | - |
dc.contributor.author | Lee, Jun Young | - |
dc.contributor.author | Kim, Sung Hwa | - |
dc.contributor.author | Lee, Jae Geun | - |
dc.contributor.author | Kim, Myoung Soo | - |
dc.contributor.author | Lee, Kwang-Woong | - |
dc.contributor.author | Joo, Dong Jin | - |
dc.contributor.author | Korean Organ Transplantation Registry Study Group | - |
dc.contributor.author | Yu, Young Dong(KOTRY Study Group) | - |
dc.contributor.author | Jo, Hye-Sung(KOTRY Study Group) | - |
dc.contributor.author | Park, PyoungJae(KOTRY Study Group) | - |
dc.contributor.author | Kim, Wan-Joon(KOTRY Study Group) | - |
dc.date.accessioned | 2022-08-17T23:40:08Z | - |
dc.date.available | 2022-08-17T23:40:08Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61339 | - |
dc.description.abstract | Chronic kidney disease (CKD) is a critical complication of liver transplants, of which non-renal risk factors are not fully understood yet. This study aimed to reveal pre- and post-transplant risk factors for CKD (<60 mL/min/1.73 m(2)), examining liver recipients with functionally intact kidneys one month after grafting using nationwide cohort data. Baseline risk factors were analyzed with multivariable Cox regression analyses and post-transplant risk factors were investigated with the time-dependent Cox model and matched analyses of time-conditional propensity scores. Of the 2274 recipients with a one-month eGFR >= 60 mL/min/1.73 m(2), 494 (22.3%) developed CKD during a mean follow-up of 36.6 +/- 14.4 months. Age, female sex, lower body mass index, pre-transplant diabetes mellitus, and lower performance status emerged as baseline risk factors for CKD. Time-dependent Cox analyses revealed that recurrent hepatocellular carcinoma (HR = 1.93, 95% CI 1.06-3.53) and infection (HR = 1.44, 95% CI 1.12-1.60) were significant post-transplant risk factors for CKD. Patients who experienced one of those factors showed a significantly higher risk of subsequent CKD compared with the matched controls who lacked these features (p = 0.013 for recurrent hepatocellular carcinoma, and p = 0.003 for infection, respectively). This study clarifies pre- and post-transplant non-renal risk factors, which lead to renal impairment after LT independently from patients' renal functional reserve. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | Non-Renal Risk Factors for Chronic Kidney Disease in Liver Recipients with Functionally Intact Kidneys at 1 Month | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/jcm11144203 | - |
dc.identifier.scopusid | 2-s2.0-85137276329 | - |
dc.identifier.wosid | 000833725600001 | - |
dc.identifier.bibliographicCitation | Journal of Clinical Medicine, v.11, no.14 | - |
dc.citation.title | Journal of Clinical Medicine | - |
dc.citation.volume | 11 | - |
dc.citation.number | 14 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | RENAL-DISEASE | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | TACROLIMUS | - |
dc.subject.keywordPlus | EVEROLIMUS | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordAuthor | liver transplantation | - |
dc.subject.keywordAuthor | chronic kidney disease | - |
dc.subject.keywordAuthor | renal dysfunction | - |
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