Augmented risk of ischemic stroke in hypertrophic cardiomyopathy patients without documented atrial fibrillation
DC Field | Value | Language |
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dc.contributor.author | Choi, You-Jung | - |
dc.contributor.author | Kim, Bongseong | - |
dc.contributor.author | Rhee, Tae-Min | - |
dc.contributor.author | Lee, Hyun-Jung | - |
dc.contributor.author | Lee, Heesun | - |
dc.contributor.author | Park, Jun-Bean | - |
dc.contributor.author | Lee, Seung-Pyo | - |
dc.contributor.author | Han, Kyung-Do | - |
dc.contributor.author | Kim, Yong-Jin | - |
dc.contributor.author | Kim, Hyung-Kwan | - |
dc.date.accessioned | 2022-10-18T00:40:37Z | - |
dc.date.available | 2022-10-18T00:40:37Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61612 | - |
dc.description.abstract | Although atrial fibrillation (AF) is a well-established risk factor for ischemic stroke (IS) in hypertrophic cardiomyopathy (HCM), the risk of IS in HCM patients without documented AF is less recognized. This nationwide population-based cohort study using Korean National Health Insurance database included 8,328 HCM patients without documented AF and 1:2 propensity score-matched 16,656 non-HCM controls between 2010 and 2016. The primary outcome was an incident IS. During a mean follow-up of 6.1 years, IS occurred in 328/8,328 (3.9%) patients with HCM and 443/16,656 (2.7%) controls. The overall incidence of IS was 0.72/100 person-years in the HCM group, which was significantly higher than that in the control group (0.44/100 person-years) (HR 1.64; 95% CI 1.424-1.895; P < 0.001). The overall incidence of IS was 1.36/100 person-years in HCM patients aged >= 65 and 2.32/100 person-years years in those with heart failure, respectively. In the HCM group, age >= 65 years (adjusted HR 2.74; 95% CI 2.156-3.486; P < 0.001) and chronic heart failure (adjusted HR 1.75; 95% CI 1.101-2.745; P = 0.018) were independent risk factors for IS. HCM patients without documented AF are at a greater risk of IS, especially in those 65 years of age or older or those with chronic heart failure. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Augmented risk of ischemic stroke in hypertrophic cardiomyopathy patients without documented atrial fibrillation | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1038/s41598-022-19895-x | - |
dc.identifier.scopusid | 2-s2.0-85138428964 | - |
dc.identifier.wosid | 000859183800006 | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.12, no.1 | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | ORAL ANTICOAGULANTS | - |
dc.subject.keywordPlus | CLINICAL PROFILE | - |
dc.subject.keywordPlus | STRATIFICATION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | DISEASE | - |
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