Detailed Information

Cited 2 time in webofscience Cited 4 time in scopus
Metadata Downloads

Orthogonally-tunable and ER-targeting fluorophores detect avian influenza virus early infection

Full metadata record
DC Field Value Language
dc.contributor.authorKang, Taewon-
dc.contributor.authorHaque, Md Mamunul-
dc.contributor.authorLee, Boran-
dc.contributor.authorHong, Kyung Tae-
dc.contributor.authorHong, Seong Cheol-
dc.contributor.authorKim, Younghun-
dc.contributor.authorLee, Jesang-
dc.contributor.authorLee, Jun-Seok-
dc.contributor.authorLee, Dongwhan-
dc.date.accessioned2022-10-25T00:40:32Z-
dc.date.available2022-10-25T00:40:32Z-
dc.date.issued2022-10-
dc.identifier.issn2041-1723-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61644-
dc.description.abstractCell-based assays can monitor virus infection at a single-cell level with high sensitivity and cost-efficiency. For this purpose, it is crucial to develop molecular probes that respond selectively to physiological changes in live cells. We report stimuli-responsive light-emitters built on a T-shaped benzimidazole platform, and consecutive borylation reactions to produce a library of homologs displaying systematic changes in fluorescence quantum yield and environmental sensitivity. We find that certain fluorophores localize selectively at the endoplasmic reticulum, and interact with proteins involved in the stress signaling pathways. Notably, the mono-borylated compound responds selectively to the stress conditions by enhancing fluorescence, and detects avian influenza virus infection at the single-cell level. Our findings demonstrate the unprecedented practical utility of the stress-responsive molecular probes to differentiate cellular states for early diagnosis.-
dc.language영어-
dc.language.isoENG-
dc.publisherNature Publishing Group-
dc.titleOrthogonally-tunable and ER-targeting fluorophores detect avian influenza virus early infection-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1038/s41467-022-33586-1-
dc.identifier.scopusid2-s2.0-85139159511-
dc.identifier.wosid000865250100001-
dc.identifier.bibliographicCitationNature Communications, v.13, no.1-
dc.citation.titleNature Communications-
dc.citation.volume13-
dc.citation.number1-
dc.type.docTypeArticle-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusENDOPLASMIC-RETICULUM STRESS-
dc.subject.keywordPlusMITOCHONDRIAL PERMEABILITY TRANSITION-
dc.subject.keywordPlusFLUORESCENT-PROBES-
dc.subject.keywordPlusCELL-DEATH-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusCULTURE-
dc.subject.keywordPlusDYES-
dc.subject.keywordPlusRED-
Files in This Item
There are no files associated with this item.
Appears in
Collections
1. Basic Science > Department of Pharmacology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Jun-Seok photo

Lee, Jun-Seok
College of Medicine (Department of Pharmacology)
Read more

Altmetrics

Total Views & Downloads

BROWSE