Prediction of functional results of percutaneous coronary interventions with virtual stenting and quantitative flow ratio
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyun-Jong | - |
dc.contributor.author | Mejia-Renteria, Hernan | - |
dc.contributor.author | Escaned, Javier | - |
dc.contributor.author | Doh, Joon-Hyung | - |
dc.contributor.author | Lee, Joo Myung | - |
dc.contributor.author | Hwang, Doyeon | - |
dc.contributor.author | Yuasa, Sonoka | - |
dc.contributor.author | Choi, Ki Hong | - |
dc.contributor.author | Jang, Ho-Jun | - |
dc.contributor.author | Jeon, Ki-Hyun | - |
dc.contributor.author | Lee, Juneyoung | - |
dc.contributor.author | Nam, Chang-Wook | - |
dc.contributor.author | Shin, Eun-Seok | - |
dc.contributor.author | Koo, Bon-Kwon | - |
dc.date.accessioned | 2022-11-23T01:40:30Z | - |
dc.date.available | 2022-11-23T01:40:30Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 1522-1946 | - |
dc.identifier.issn | 1522-726X | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61816 | - |
dc.description.abstract | Background The clinical value of residual quantitative flow ratio (rQFR), a novel function of QFR technique, is unknown. Aim We investigated the clinical value of rQFR, aimed to predict residual ischemia after virtual percutaneous coronary intervention (vPCI). Methods This is a substudy of the COE-PERSPECTIVE registry, which investigated the prognostic value of post-PCI fractional flow reserve (FFR). From pre-PCI angiograms, QFR and rQFR were analyzed and their diagnostic performance was assessed at blinded fashion using pre-PCI FFR and post-PCI FFR as reference, respectively. The prognostic value of rQFR after vPCI was assessed according to vessel-oriented composite outcome (VOCO) at 2 years. Results We analyzed 274 patients (274 vessels) with FFR-based ischemic causing lesions (49%) from 555 screened patients. Pre-PCI QFR and FFR were 0.63 ± 0.10 and 0.66 ± 0.11 (R = 0.756, p < 0.001). rQFR after vPCI and FFR after real PCI were 0.93 ± 0.06 and 0.86 ± 0.07 (R = 0.528, p < 0.001). The mean difference between rQFR and post-PCI FFR was 0.068 (95% limit of agreement: −0.05 to 0.19). Diagnostic performance of rQFR to predict residual ischemia after PCI was good (area under the curve [AUC]: 0.856 [0.804−0.909], p < 0.001). rQFR predicted well the incidence of 2-year VOCO after index PCI (AUC: 0.712 [0.555−0.869], p = 0.041), being similar to that of actual post-PCI FFR (AUC: 0.691 [0.512−0.870], p = 0.061). rQFR ≤0.89 was associated with increased risk of 2-year VOCO (hazard ratio [HR]: 12.9 [2.32−71.3], p = 0.0035). This difference was mainly driven by a higher rate of target vessel revascularization (HR: 16.98 [2.33−123.29], p = 0.0051). Conclusions rQFR estimated from pre-PCI angiography and virtual coronary stenting mildly overestimated functional benefit of PCI. However, it well predicted suboptimal functional result and long-term vessel-related clinical events. Clinical Trial Registration Influence of fractional flow reserve on the Clinical OutcomEs of PERcutaneouS Coronary Intervention (COE-PESPECTIVE) Registry, NCT01873560 | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Prediction of functional results of percutaneous coronary interventions with virtual stenting and quantitative flow ratio | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/ccd.30451 | - |
dc.identifier.scopusid | 2-s2.0-85141380053 | - |
dc.identifier.wosid | 000877531600001 | - |
dc.identifier.bibliographicCitation | Catheterization and Cardiovascular Interventions, v.100, no.7, pp 1208 - 1217 | - |
dc.citation.title | Catheterization and Cardiovascular Interventions | - |
dc.citation.volume | 100 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1208 | - |
dc.citation.endPage | 1217 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | DIAGNOSTIC-ACCURACY | - |
dc.subject.keywordPlus | RESERVE | - |
dc.subject.keywordPlus | ANGIOGRAPHY | - |
dc.subject.keywordAuthor | coronary angiography | - |
dc.subject.keywordAuthor | coronary physiology | - |
dc.subject.keywordAuthor | coronary stents | - |
dc.subject.keywordAuthor | fractional flow reserve | - |
dc.subject.keywordAuthor | PCI optimization | - |
dc.subject.keywordAuthor | PCI outcomes | - |
dc.subject.keywordAuthor | percutaneous coronary intervention | - |
dc.subject.keywordAuthor | quantitative flow ratio | - |
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