Feasibility and safety of inserting transient biodegradable stents in the pylorus during pylorus-preserving gastrectomy for gastric cancer: a preliminary study in a porcine for proof of concept
DC Field | Value | Language |
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dc.contributor.author | Park, Ji-Hyeon | - |
dc.contributor.author | Yoon, Hyesung | - |
dc.contributor.author | Kwak, Yoon Jin | - |
dc.contributor.author | Wang, Chaojie | - |
dc.contributor.author | Alzahrani, Khalid Mohammed | - |
dc.contributor.author | Wang, Sen | - |
dc.contributor.author | Alzahrani, Fadhel Dhaifallah H. | - |
dc.contributor.author | Kim, Hyun Myong | - |
dc.contributor.author | Koo, Eunhee | - |
dc.contributor.author | Yoo, Ja Eun | - |
dc.contributor.author | Choi, Jong-Ho | - |
dc.contributor.author | Park, Shin-Hoo | - |
dc.contributor.author | Kong, Seong-Ho | - |
dc.contributor.author | Park, Do Joong | - |
dc.contributor.author | Lee, Hyuk-Joon | - |
dc.contributor.author | Yang, Han-Kwang | - |
dc.date.accessioned | 2022-12-13T00:40:32Z | - |
dc.date.available | 2022-12-13T00:40:32Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 1436-3291 | - |
dc.identifier.issn | 1436-3305 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61941 | - |
dc.description.abstract | Background To evaluate whether insertion of self-biodegradable stent into the pylorus to prevent delayed-gastric emptying after pylorus-preserving gastrectomy is feasible and safe through porcine experiment. Methods Self-biodegradable dumbbell-shaped pyloric stents were designed from absorbable suture materials: poly(glycolide-co-caprolactone) (PGCL) or poly-p-dioxanone (PPDO). After gastrotomy on ten pigs, each stent was inserted: two shams, four PGCL stents, and four PPDO stents. Body weight (Bwt), body temperature (BT), complete blood cell (CBC) count, and plain X-ray were evaluated. On postoperative day (POD) 13, euthanasia was performed for histologic evaluation. Results Operation was successfully performed in all ten pigs. Without tagging suture, both stents migrated before POD 3. The migration was delayed up to POD 13, when the tagging sutures (-t) were applied between stent and stomach wall. Self-degradation of PGCL started from POD 3, and stents were completely excreted from the abdomen by POD 8. Although PPDO were also weakened as self-degradation progressed, its shape was maintained in gastrointestinal tract for 13 days. Unexpected sudden death occurred in the pig with PPDO-t2 on POD 10, which is more likely due to acute volvulus rather than stent-related complication. There was no significant difference between three groups in terms of Bwt, BT, CBC, and histology (sham vs. PGCL vs. PPDO, all p > 0.05). Conclusion The concept of biodegradable stents made of absorbent suture material seems feasible in porcine experiment. Among them, PGCL which has shown rapid absorption, appears to be a more suitable material for transient pyloric absorbable stent when considering safety aspect. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Springer Verlag | - |
dc.title | Feasibility and safety of inserting transient biodegradable stents in the pylorus during pylorus-preserving gastrectomy for gastric cancer: a preliminary study in a porcine for proof of concept | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1007/s10120-022-01350-5 | - |
dc.identifier.scopusid | 2-s2.0-85142455483 | - |
dc.identifier.wosid | 000886808600001 | - |
dc.identifier.bibliographicCitation | Gastric Cancer, v.26, no.1, pp 155 - 166 | - |
dc.citation.title | Gastric Cancer | - |
dc.citation.volume | 26 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 155 | - |
dc.citation.endPage | 166 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | SHORT-TERM OUTCOMES | - |
dc.subject.keywordPlus | DISTAL GASTRECTOMY | - |
dc.subject.keywordPlus | PLACEMENT | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordAuthor | Biodegradable stent | - |
dc.subject.keywordAuthor | Poly(glycolide-co-caprolactone) | - |
dc.subject.keywordAuthor | Poly-p-dioxanone | - |
dc.subject.keywordAuthor | Pylorus-preserving gastrectomy | - |
dc.subject.keywordAuthor | Delayed gastric emptying | - |
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