Investigation of D-Amino Acid-Based Surfactants and Nanocomposites with Gold and Silica Nanoparticles as against Multidrug-Resistant Bacteria Agents
DC Field | Value | Language |
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dc.contributor.author | Shim, Jae Ho | - |
dc.contributor.author | Gwak, Sungduk | - |
dc.contributor.author | Ahn, Byung Kook | - |
dc.contributor.author | Han, Hogyu | - |
dc.contributor.author | Hong, Yeonsun | - |
dc.contributor.author | Shin, Ok Sarah | - |
dc.date.accessioned | 2023-01-04T00:40:02Z | - |
dc.date.available | 2023-01-04T00:40:02Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 2470-1343 | - |
dc.identifier.issn | 2470-1343 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61989 | - |
dc.description.abstract | D-amino acid-based surfactants (D-AASs) were synthesized and their antimicrobial activity was evaluated. N-alpha-lauroyl-D-arginine ethyl ester hydrochloride (D-LAE), D-proline dodecyl ester (D-PD), and D-alanine dodecyl ester (D-AD) were found to have antibacterial activity against both Gram-positive and-negative bacteria, but less efficacy against Gram-negative bacteria. For these reasons, combining antimicrobial agents with nanoparticles is a promising technique for improving their antibacterial properties to eliminate drug-resistant pathogens. D-LAE coated on gold (AuNP) and silica (SiNP) nanoparticles has more efficient antibacterial activity than that of D-LAE alone. However, unlike D-LAE, D-PD has enhanced antibacterial activity upon being coated on AuNP. The antibacterial D-AASs and their nanocomposites with nanoparticles were synthesized in an environmentally friendly manner and are expected to be valuable new antimicrobial agents against multidrug-resistant (MDR) pathogens. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACS Publications | - |
dc.title | Investigation of D-Amino Acid-Based Surfactants and Nanocomposites with Gold and Silica Nanoparticles as against Multidrug-Resistant Bacteria Agents | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1021/acsomega.2c04220 | - |
dc.identifier.scopusid | 2-s2.0-85143889817 | - |
dc.identifier.wosid | 000895313000001 | - |
dc.identifier.bibliographicCitation | ACS OMEGA, v.7, no.50, pp 46146 - 46155 | - |
dc.citation.title | ACS OMEGA | - |
dc.citation.volume | 7 | - |
dc.citation.number | 50 | - |
dc.citation.startPage | 46146 | - |
dc.citation.endPage | 46155 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | ANTIMICROBIAL PEPTIDES | - |
dc.subject.keywordPlus | ANTIBACTERIAL ACTIVITY | - |
dc.subject.keywordPlus | THEORETICAL DFT | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | SPECTRA | - |
dc.subject.keywordPlus | ALANINE | - |
dc.subject.keywordPlus | RAMAN | - |
dc.subject.keywordPlus | ABSORPTION | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.subject.keywordPlus | GLYCINE | - |
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