Bifurcation strategies using second-generation drug-eluting stents on clinical outcomes in diabetic patients
DC Field | Value | Language |
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dc.contributor.author | Cha, Jung-Joon | - |
dc.contributor.author | Hong, Soon Jun | - |
dc.contributor.author | Kim, Ju Hyeon | - |
dc.contributor.author | Lim, Subin | - |
dc.contributor.author | Joo, Hyung Joon | - |
dc.contributor.author | Park, Jae Hyoung | - |
dc.contributor.author | Yu, Cheol Woong | - |
dc.contributor.author | Kang, Jeehoon | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.contributor.author | Gwon, Hyeon-Cheol | - |
dc.contributor.author | Chun, Woo Jung | - |
dc.contributor.author | Hur, Seung-Ho | - |
dc.contributor.author | Han, Seung Hwan | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.contributor.author | Chae, In-Ho | - |
dc.contributor.author | Jeong, Jin-Ok | - |
dc.contributor.author | Heo, Jung Ho | - |
dc.contributor.author | Yoon, Junghan | - |
dc.contributor.author | Park, Jong-Seon | - |
dc.contributor.author | Hong, Myeong-Ki | - |
dc.contributor.author | Doh, Joon-Hyung | - |
dc.contributor.author | Cha, Kwang Soo | - |
dc.contributor.author | Kim, Doo-Il | - |
dc.contributor.author | Lee, Sang Yeub | - |
dc.contributor.author | Chang, Kiyuk | - |
dc.contributor.author | Hwang, Byung-Hee | - |
dc.contributor.author | Choi, So-Yeon | - |
dc.contributor.author | Jeong, Myung Ho | - |
dc.contributor.author | Song, Young Bin | - |
dc.contributor.author | Choi, Ki Hong | - |
dc.contributor.author | Nam, Chang-Wook | - |
dc.contributor.author | Koo, Bon-Kwon | - |
dc.contributor.author | Lim, Do-Sun | - |
dc.date.accessioned | 2023-01-26T00:40:10Z | - |
dc.date.available | 2023-01-26T00:40:10Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 2297-055X | - |
dc.identifier.issn | 2297-055X | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62177 | - |
dc.description.abstract | Background: Diabetes mellitus (DM) is a critical risk factor for the pathogenesis and progression of coronary artery disease, with a higher prevalence of complex coronary artery disease, including bifurcation lesions. This study aimed to elucidate the optimal stenting strategy for coronary bifurcation lesions in patients with DM.Methods: A total of 905 patients with DM and bifurcation lesions treated with second-generation drug-eluting stents (DES) from a multicenter retrospective patient cohort were analyzed. The primary outcome was the 5-year incidence of target lesion failure (TLF), which was defined as a composite of cardiac death, target vessel myocardial infarction, and target lesion revascularization.Results: Among all patients with DM with significant bifurcation lesions, 729 (80.6%) and 176 (19.4%) were treated with one- and two-stent strategies, respectively. TLF incidence differed according to the stenting strategy during the mean follow-up of 42 +/- 20 months. Among the stent strategies, T- and V-stents were associated with a higher TLF incidence than one-stent strategy (24.0 vs. 7.3%, p < 0.001), whereas no difference was observed in TLF between the one-stent strategy and crush or culotte technique (7.3 vs. 5.9%, p = 0.645). The T- or V-stent technique was an independent predictor of TLF in multivariate analysis (hazard ratio, 3.592; 95% confidence interval, 2.117-6.095; p < 0.001). Chronic kidney disease, reduced left ventricular ejection fraction, and left main bifurcation were independent predictors of TLF in patients with DM.Conclusion: T- or V-stenting in patients with DM resulted in increased cardiovascular events after second-generation DES implantation. | - |
dc.description.abstract | Background: Diabetes mellitus (DM) is a critical risk factor for the pathogenesis and progression of coronary artery disease, with a higher prevalence of complex coronary artery disease, including bifurcation lesions. This study aimed to elucidate the optimal stenting strategy for coronary bifurcation lesions in patients with DM. Methods: A total of 905 patients with DM and bifurcation lesions treated with second-generation drug-eluting stents (DES) from a multicenter retrospective patient cohort were analyzed. The primary outcome was the 5-year incidence of target lesion failure (TLF), which was defined as a composite of cardiac death, target vessel myocardial infarction, and target lesion revascularization. Results: Among all patients with DM with significant bifurcation lesions, 729 (80.6%) and 176 (19.4%) were treated with one- and two-stent strategies, respectively. TLF incidence differed according to the stenting strategy during the mean follow-up of 42 ± 20 months. Among the stent strategies, T- and V-stents were associated with a higher TLF incidence than one-stent strategy (24.0 vs. 7.3%, p < 0.001), whereas no difference was observed in TLF between the one-stent strategy and crush or culotte technique (7.3 vs. 5.9%, p = 0.645). The T- or V-stent technique was an independent predictor of TLF in multivariate analysis (hazard ratio, 3.592; 95% confidence interval, 2.117–6.095; p < 0.001). Chronic kidney disease, reduced left ventricular ejection fraction, and left main bifurcation were independent predictors of TLF in patients with DM. Conclusion: T- or V-stenting in patients with DM resulted in increased cardiovascular events after second-generation DES implantation. Clinical trial registration: https://clinicaltrials.gov/ct2/show/NCT03068494?term=03068494&draw=2&rank=1, identifier: NCT03068494 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Bifurcation strategies using second-generation drug-eluting stents on clinical outcomes in diabetic patients | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3389/fcvm.2022.1018802 | - |
dc.identifier.scopusid | 2-s2.0-85145504220 | - |
dc.identifier.wosid | 000907583300001 | - |
dc.identifier.bibliographicCitation | Frontiers in Cardiovascular Medicine, v.9 | - |
dc.citation.title | Frontiers in Cardiovascular Medicine | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | CORONARY STENTS | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordAuthor | coronary bifurcation angioplasty | - |
dc.subject.keywordAuthor | diabetes mellitus | - |
dc.subject.keywordAuthor | stent strategy | - |
dc.subject.keywordAuthor | second-generation drug-eluting stent | - |
dc.subject.keywordAuthor | clinical outcome | - |
dc.subject.keywordAuthor | percutaneous coronary intervention (complex PCI) | - |
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