MRI-Compatible, Transparent PEDOT:PSS Neural Implants for the Alleviation of Neuropathic Pain with Motor Cortex Stimulation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Young Uk | - |
dc.contributor.author | Kim, Kyeongmin | - |
dc.contributor.author | Dutta, Ankan | - |
dc.contributor.author | Park, Sang Hoon | - |
dc.contributor.author | Lee, Ju Young | - |
dc.contributor.author | Kim, Hyun Woo | - |
dc.contributor.author | Park, Jieon | - |
dc.contributor.author | Kim, Jiwon | - |
dc.contributor.author | Min, Won Kyung | - |
dc.contributor.author | Won, Chihyeong | - |
dc.contributor.author | Park, Jaejin | - |
dc.contributor.author | Kim, Yujin | - |
dc.contributor.author | Kim, Jong Youl | - |
dc.contributor.author | Lee, Taeyoon | - |
dc.contributor.author | Kim, Hyun Jae | - |
dc.contributor.author | Kim, Donghyun | - |
dc.contributor.author | Lee, Jong Eun | - |
dc.contributor.author | Min, Byung-Wook | - |
dc.contributor.author | Cho, Il-Joo | - |
dc.contributor.author | Lee, Bae Hwan | - |
dc.contributor.author | Cheng, Huanyu | - |
dc.contributor.author | Cha, Myeounghoon | - |
dc.contributor.author | Yu, Ki Jun | - |
dc.date.accessioned | 2023-11-20T01:40:51Z | - |
dc.date.available | 2023-11-20T01:40:51Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.issn | 1616-3028 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64337 | - |
dc.description.abstract | Simultaneous monitoring of electrophysiology and magnetic resonance imaging (MRI) could guide the innovative diagnosis and treatment of various neurodegenerative diseases that are previously impossible. However, this technique is difficult because the existing metal-based implantable neural interface for electrophysiology is not free from signal distortions from its intrinsic magnetic susceptibility while performing an MRI of the implanted area of the neural interface. Moreover, brain tissue heating from neural implants generated by the radiofrequency field from MRI poses potential hazards for patients. Previous studies with soft polymer-based electrode arrays provide relatively suitable MRI compatibility but does not guarantee high-resolution electrophysiological signal acquisition and stimulation performance. Here, MRI compatible, optically transparent flexible implantable device capable of electrophysiological multichannel mapping and electrical stimulation is introduced. Using the device, neuropathic pain (NP) relief with a 30-channel electrophysiological mapping of the somatosensory area before and after motor cortex stimulation (MCS) in allodynia rats after noxious stimulation is confirmed. Additionally, artifact-free manganese-enhanced MRI of dramatic relief of pain-related region activity by MCS is demonstrated. Furthermore, artifact-free optogenetics with transgenic mice is also investigated by recording light-evoked potentials. These results suggest a promising neuro-prosthetic for analyzing and modulating spatiotemporal neurodynamic without MRI or optical modality resolution constraints. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.title | MRI-Compatible, Transparent PEDOT:PSS Neural Implants for the Alleviation of Neuropathic Pain with Motor Cortex Stimulation | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1002/adfm.202310908 | - |
dc.identifier.scopusid | 2-s2.0-85174930336 | - |
dc.identifier.wosid | 001091258900001 | - |
dc.identifier.bibliographicCitation | Advanced Functional Materials | - |
dc.citation.title | Advanced Functional Materials | - |
dc.type.docType | Article; Early Access | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | MAGNETIC-SUSCEPTIBILITY | - |
dc.subject.keywordPlus | ELECTRODE ARRAYS | - |
dc.subject.keywordPlus | ABSORPTION RATE | - |
dc.subject.keywordPlus | CHALLENGES | - |
dc.subject.keywordPlus | OPTOGENETICS | - |
dc.subject.keywordPlus | INTERFACES | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | FILMS | - |
dc.subject.keywordPlus | FMRI | - |
dc.subject.keywordAuthor | MRI compatible neural implants | - |
dc.subject.keywordAuthor | neuropathic pain alleviation | - |
dc.subject.keywordAuthor | poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) transparent electrodes | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.