Transcriptomic Profiling of Reproductive Age Marmoset Monkey Ovaries
DC Field | Value | Language |
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dc.contributor.author | Kim, Yoon Young | - |
dc.contributor.author | Kim, Sung Woo | - |
dc.contributor.author | Kim, Eunjin | - |
dc.contributor.author | Kim, Yong Jin | - |
dc.contributor.author | Kang, Byeong-Cheol | - |
dc.contributor.author | Ku, Seung-Yup | - |
dc.date.accessioned | 2024-02-06T02:00:06Z | - |
dc.date.available | 2024-02-06T02:00:06Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.issn | 1933-7191 | - |
dc.identifier.issn | 1933-7205 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65374 | - |
dc.description.abstract | The decline in ovarian reserve and the aging of the ovaries is a significant concern for women, particularly in the context of delayed reproduction. However, there are ethical limitations and challenges associated with conducting long-term studies to understand and manipulate the mechanisms that regulate ovarian aging in human. The marmoset monkey offers several advantages as a reproductive model, including a shorter gestation period and similar reproductive physiology to that of human. Additionally, they have a relatively long lifespan compared to other mammals, making them suitable for long-term studies. In this study, we focused on analyzing the structural characteristics of the marmoset ovary and studying the mRNA expression of 244 genes associated with ovarian aging. We obtained ovaries from marmosets at three different reproductive stages: pre-pubertal (1.5 months), reproductive (82 months), and menopausal (106 months) ovaries. The structural analyses revealed the presence of numerous mitochondria and lipid droplets in the marmoset ovaries. Many of the genes expressed in the ovaries were involved in multicellular organism development and transcriptional regulation. Additionally, we identified the expression of protein-binding genes. Within the expressed genes, VEGFA and MMP9 were found to be critical for regulating ovarian reserve. An intriguing finding of the study was the strong correlation between genes associated with female infertility and genes related to fibrosis and wound healing. The authors suggest that this correlation might be a result of the repeated rupture and subsequent healing processes occurring in the ovary due to the menstrual cycle, potentially leading to the indirect onset of fibrosis. The expression profile of ovarian aging-related gene set in the marmoset monkey ovaries highlight the need for further studies to explore the relationship between fibrosis, wound healing, and ovarian aging. © 2023, The Author(s), under exclusive licence to Society for Reproductive Investigation. | - |
dc.format.extent | 15 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SAGE Publications | - |
dc.title | Transcriptomic Profiling of Reproductive Age Marmoset Monkey Ovaries | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1007/s43032-023-01342-5 | - |
dc.identifier.scopusid | 2-s2.0-85170849844 | - |
dc.identifier.wosid | 001068060300002 | - |
dc.identifier.bibliographicCitation | Reproductive Sciences, v.31, no.1, pp 81 - 95 | - |
dc.citation.title | Reproductive Sciences | - |
dc.citation.volume | 31 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 81 | - |
dc.citation.endPage | 95 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Obstetrics & GynecologyReproductive Biology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & GynecologyReproductive Biology | - |
dc.subject.keywordPlus | COMMON MARMOSET | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | HORMONE | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | Marmoset | - |
dc.subject.keywordAuthor | Ovarian reserve | - |
dc.subject.keywordAuthor | Ovary | - |
dc.subject.keywordAuthor | Transcriptome profiling | - |
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