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Omicron BA.2 breakthrough infection elicits CD8+ T cell responses recognizing the spike of later Omicron subvariants

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dc.contributor.authorKim, Sang-Hoon-
dc.contributor.authorKim, Jihye-
dc.contributor.authorJung, Sungmin-
dc.contributor.authorNoh, Ji Yun-
dc.contributor.authorKim, Jinnam-
dc.contributor.authorPark, Heedo-
dc.contributor.authorSong, Young Goo-
dc.contributor.authorPeck, Kyong Ran-
dc.contributor.authorPark, Su-Hyung-
dc.contributor.authorPark, Man-Seong-
dc.contributor.authorKo, Jae-Hoon-
dc.contributor.authorSong, Joon Young-
dc.contributor.authorChoi, Jun Yong-
dc.contributor.authorJung, Min Kyung-
dc.contributor.authorShin, Eui-Cheol-
dc.date.accessioned2024-02-06T06:30:06Z-
dc.date.available2024-02-06T06:30:06Z-
dc.date.issued2024-01-
dc.identifier.issn2470-9468-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65393-
dc.description.abstractHere, we examine peripheral blood memory T cell responses against the SARS-CoV-2 BA.4/BA.5 variant spike among vaccinated individuals with or without Omicron breakthrough infections. We provide evidence supporting a lack of original antigenic sin in CD8+ T cell responses targeting the spike. We show that BNT162b2-induced memory T cells respond to the BA.4/BA.5 spike. Among individuals with BA.1/BA.2 breakthrough infections, IFN-γ-producing CD8+ T cell responses against the BA.4/BA.5 spike increased. In a subgroup with BA.2 breakthrough infections, IFN-γ-producing CD8+ T cell responses against the BA.2-mutated spike region increased and correlated directly with responses against the BA.4/BA.5 spike, indicating that BA.2 spike-specific CD8+ T cells elicited by BA.2 breakthrough infection cross-react with the BA.4/BA.5 spike. We identified CD8+ T cell epitope peptides that are present in the spike of BA.2 and BA.4/BA.5 but not the original spike. These peptides are fully conserved in the spike of now-dominant XBB lineages. Our study shows that breakthrough infection by early Omicron subvariants elicits CD8+ T cell responses that recognize epitopes within the spike of newly emerging subvariants.-
dc.language영어-
dc.language.isoENG-
dc.publisherAmerican Association for the Advancement of Science-
dc.titleOmicron BA.2 breakthrough infection elicits CD8+ T cell responses recognizing the spike of later Omicron subvariants-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1126/sciimmunol.ade6132-
dc.identifier.scopusid2-s2.0-85182865740-
dc.identifier.wosid001184652400001-
dc.identifier.bibliographicCitationScience immunology, v.9, no.91, pp eade6132-
dc.citation.titleScience immunology-
dc.citation.volume9-
dc.citation.number91-
dc.citation.startPageeade6132-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaImmunology-
dc.relation.journalWebOfScienceCategoryImmunology-
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