Omicron BA.2 breakthrough infection elicits CD8+ T cell responses recognizing the spike of later Omicron subvariants
DC Field | Value | Language |
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dc.contributor.author | Kim, Sang-Hoon | - |
dc.contributor.author | Kim, Jihye | - |
dc.contributor.author | Jung, Sungmin | - |
dc.contributor.author | Noh, Ji Yun | - |
dc.contributor.author | Kim, Jinnam | - |
dc.contributor.author | Park, Heedo | - |
dc.contributor.author | Song, Young Goo | - |
dc.contributor.author | Peck, Kyong Ran | - |
dc.contributor.author | Park, Su-Hyung | - |
dc.contributor.author | Park, Man-Seong | - |
dc.contributor.author | Ko, Jae-Hoon | - |
dc.contributor.author | Song, Joon Young | - |
dc.contributor.author | Choi, Jun Yong | - |
dc.contributor.author | Jung, Min Kyung | - |
dc.contributor.author | Shin, Eui-Cheol | - |
dc.date.accessioned | 2024-02-06T06:30:06Z | - |
dc.date.available | 2024-02-06T06:30:06Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.issn | 2470-9468 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65393 | - |
dc.description.abstract | Here, we examine peripheral blood memory T cell responses against the SARS-CoV-2 BA.4/BA.5 variant spike among vaccinated individuals with or without Omicron breakthrough infections. We provide evidence supporting a lack of original antigenic sin in CD8+ T cell responses targeting the spike. We show that BNT162b2-induced memory T cells respond to the BA.4/BA.5 spike. Among individuals with BA.1/BA.2 breakthrough infections, IFN-γ-producing CD8+ T cell responses against the BA.4/BA.5 spike increased. In a subgroup with BA.2 breakthrough infections, IFN-γ-producing CD8+ T cell responses against the BA.2-mutated spike region increased and correlated directly with responses against the BA.4/BA.5 spike, indicating that BA.2 spike-specific CD8+ T cells elicited by BA.2 breakthrough infection cross-react with the BA.4/BA.5 spike. We identified CD8+ T cell epitope peptides that are present in the spike of BA.2 and BA.4/BA.5 but not the original spike. These peptides are fully conserved in the spike of now-dominant XBB lineages. Our study shows that breakthrough infection by early Omicron subvariants elicits CD8+ T cell responses that recognize epitopes within the spike of newly emerging subvariants. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.title | Omicron BA.2 breakthrough infection elicits CD8+ T cell responses recognizing the spike of later Omicron subvariants | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1126/sciimmunol.ade6132 | - |
dc.identifier.scopusid | 2-s2.0-85182865740 | - |
dc.identifier.wosid | 001184652400001 | - |
dc.identifier.bibliographicCitation | Science immunology, v.9, no.91, pp eade6132 | - |
dc.citation.title | Science immunology | - |
dc.citation.volume | 9 | - |
dc.citation.number | 91 | - |
dc.citation.startPage | eade6132 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
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