Exploring Embryo-Ototoxic Effects: Insights into Deodorant-Induced Hair Cell Damage in Zebrafish
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Hee Soo | - |
dc.contributor.author | Hyun, Kyung Tae | - |
dc.contributor.author | Hong, Sumin | - |
dc.contributor.author | Park, Saemi | - |
dc.contributor.author | Han, Eunjung | - |
dc.contributor.author | Baek, Hyun woo | - |
dc.contributor.author | Lee, Yun Kyoung | - |
dc.contributor.author | Lim, Kang Hyeon | - |
dc.contributor.author | Rah, Yoon Chan | - |
dc.contributor.author | Choi, June | - |
dc.date.accessioned | 2024-02-13T03:00:09Z | - |
dc.date.available | 2024-02-13T03:00:09Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65420 | - |
dc.description.abstract | Our study investigated the embryo-ototoxic effects of deodorant2 (DA2) on zebrafish embryos, which serve as valuable model organisms due to genetic and physiological similarities to humans. We focused on understanding DA2's impact on zebrafish hair cells, which are vital for sensory perception and balance regulation. DA2, provided by the Ministry of Environment, Republic of Korea, was used at 460 mu g/mL in dimethyl sulfoxide (DMSO), with a 0.43% DMSO solvent control group. Three experiments, each using 10 zebrafish specimens from each group, showed an initial 13% hair cell count reduction in the DA2-exposed group. Subsequent experiments demonstrated reductions of 37% and 22%, each with one mortality case. Statistical analysis revealed a significant 24% hair cell count reduction in the DA2-exposed group. We also assessed DA2's impact on zebrafish behavior. Although not statistically significant, differences in distances traveled (0.33-0.39, 95% confidence interval: -0.46-1.1, p = 0.2033) and latencies (-0.016-0.018, 95% confidence interval: -0.052-0.021, p = 0.1917) hinted at negative effects. These results highlight DA2's ototoxic properties affecting zebrafish auditory systems and behavior. Further investigation into DA2's effects on aquatic organisms and potential mitigation strategies are essential. These findings contribute to understanding DA2's safety profile, benefiting aquatic ecosystems and human health assessments. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Exploring Embryo-Ototoxic Effects: Insights into Deodorant-Induced Hair Cell Damage in Zebrafish | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/ijms25020948 | - |
dc.identifier.scopusid | 2-s2.0-85183264198 | - |
dc.identifier.wosid | 001151558200001 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.25, no.2 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 25 | - |
dc.citation.number | 2 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | DANIO-RERIO | - |
dc.subject.keywordPlus | LATERAL-LINE | - |
dc.subject.keywordPlus | STARTLE RESPONSE | - |
dc.subject.keywordPlus | TRICLOSAN | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | TOLUENE | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | zebrafish | - |
dc.subject.keywordAuthor | ototoxicity | - |
dc.subject.keywordAuthor | hair cell | - |
dc.subject.keywordAuthor | audiologic result | - |
dc.subject.keywordAuthor | behavior change | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.