The Role of the Aryl Hydrocarbon Receptor in Vascular Factors Related to Preeclampsia in a Smoking Mouse Model
DC Field | Value | Language |
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dc.contributor.author | Kim, Ho-Yeon | - |
dc.contributor.author | Seok, Ye-Seon | - |
dc.contributor.author | Moon, Hye-Yeon | - |
dc.contributor.author | Cho, Geum-Joon | - |
dc.contributor.author | Ahn, Ki-Hoon | - |
dc.contributor.author | Hong, Soon-Cheol | - |
dc.contributor.author | Oh, Min-Jeong | - |
dc.contributor.author | Kim, Hai-Joong | - |
dc.date.accessioned | 2024-02-13T03:00:09Z | - |
dc.date.available | 2024-02-13T03:00:09Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.issn | 1467-3037 | - |
dc.identifier.issn | 1467-3045 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65421 | - |
dc.description.abstract | Smoking cigarettes is known to lower the risk of preeclampsia. The objective of this study is to evaluate the effect of smoking on the expression of soluble FMS-like tyrosine kinase-1 (sFlt-1), vascular endothelial growth factor (VEGF), and endoglin (sEng)-1 and the role of the aryl hydrocarbon receptor (AhR) in pregnant mice. We developed a smoking mouse model using a gas-filling system. One or two cigarettes per day were exposed to each of the five pregnant mice for five days a week throughout pregnancy. AhR agonist and antagonist were injected. Serum levels and expression in the placenta of sFlt-1, VEGF, and sEng-1 were analyzed and compared among the cigarette smoke and no-exposure groups after delivery. Compared to the no-smoke exposure group, the serum level of sFlt-1 was significantly decreased in the two-cigarette-exposed group (p < 0.001). When the AhR antagonist was added to the two-cigarette-exposed group, sFlt-1 levels were significantly increased compared to the two-cigarette group (p = 0.002). The levels of sFlt-1 in the AhR antagonist group did not change regardless of two-cigarette exposure (p = 0.064). With the AhR agonist, sFlt-1 decreased significantly compared to the control (p = 0.001) and AhR antagonist group (p = 0.002). The sFlt-1 level was significantly decreased after the injection of the AhR agonist compared to the control group (p = 0.001). Serum levels of VEGF were significantly decreased in the one-cigarette-exposed group compared to the control group; however, there was no difference between the control and the two-cigarette-exposed groups. The placental expression of sFlt-1, VEGF, and sEng were inconsistent. This study offers insights into the potential role of AhR on antiangiogenic sFlt-1 associated with preeclampsia. It may support the invention of a new treatment strategy for preeclampsia using AhR activation. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | The Role of the Aryl Hydrocarbon Receptor in Vascular Factors Related to Preeclampsia in a Smoking Mouse Model | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.3390/cimb46010048 | - |
dc.identifier.scopusid | 2-s2.0-85183923075 | - |
dc.identifier.wosid | 001151913800001 | - |
dc.identifier.bibliographicCitation | Current Issues in Molecular Biology, v.46, no.1, pp 741 - 752 | - |
dc.citation.title | Current Issues in Molecular Biology | - |
dc.citation.volume | 46 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 741 | - |
dc.citation.endPage | 752 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | CIRCULATING ANGIOGENIC FACTORS | - |
dc.subject.keywordPlus | CIGARETTE-SMOKE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | DIOXIN RECEPTOR | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | PREGNANCY | - |
dc.subject.keywordPlus | NICOTINE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | PLACENTAS | - |
dc.subject.keywordAuthor | aryl hydrocarbon receptor | - |
dc.subject.keywordAuthor | soluble FMS-like tyrosine kinase | - |
dc.subject.keywordAuthor | cigarette | - |
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