Sticky and Strain-Gradient Artificial Epineurium for Sutureless Nerve Repair in Rodents and Nonhuman Primates
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seong, Duhwan | - |
dc.contributor.author | Choi, Yeonsun | - |
dc.contributor.author | Choi, In Cheul | - |
dc.contributor.author | Lee, Jaebeom | - |
dc.contributor.author | Choi, Jae Hyuk | - |
dc.contributor.author | Park, Ji Hun | - |
dc.contributor.author | Nam, Jae Jun | - |
dc.contributor.author | Ju, Jaewon | - |
dc.contributor.author | Ryoo, Hyun Jae | - |
dc.contributor.author | Kwak, Donghee | - |
dc.contributor.author | Lee, Joonyeol | - |
dc.contributor.author | Kim, Seong-Gi | - |
dc.contributor.author | Kim, Dong Hwee | - |
dc.contributor.author | Park, Jong Woong | - |
dc.contributor.author | Shin, Mikyung | - |
dc.contributor.author | Son, Donghee | - |
dc.date.accessioned | 2024-02-27T02:00:05Z | - |
dc.date.available | 2024-02-27T02:00:05Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.issn | 0935-9648 | - |
dc.identifier.issn | 1521-4095 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65530 | - |
dc.description.abstract | The need for the development of soft materials capable of stably adhering to nerve tissues without any suturing followed by additional damages is at the fore at a time when success in postoperative recovery depends largely on the surgical experience and/or specialized microsuturing skills of the surgeon. Despite fully recognizing such prerequisite conditions, designing the materials with robust adhesion to wet nerves as well as acute/chronic anti-inflammation remains to be resolved. Herein, a sticky and strain-gradient artificial epineurium (SSGAE) that overcomes the most critically challenging aspect for realizing sutureless repair of severely injured nerves is presented. In this regard, the SSGAE with a skin-inspired hierarchical structure entailing strain-gradient layers, anisotropic Janus layers including hydrophobic top and hydrophilic bottom surfaces, and synergistic self-healing capabilities enables immediate and stable neurorrhaphy in both rodent and nonhuman primate models, indicating that the bioinspired materials strategy significantly contributes to translational medicine for effective peripheral nerve repair. A key feature in the materials design of wet adhesive, "a sticky and strain-gradient artificial epineurium (SSGAE) with skin-inspired hierarchical structure entailing strain-gradient layers, Janus hydrophilic/hydrophobic surfaces, and even self-healing property", which enables immediate and stable neurorrhaphy, is reported. image | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.title | Sticky and Strain-Gradient Artificial Epineurium for Sutureless Nerve Repair in Rodents and Nonhuman Primates | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1002/adma.202307810 | - |
dc.identifier.scopusid | 2-s2.0-85183733196 | - |
dc.identifier.wosid | 001155414900001 | - |
dc.identifier.bibliographicCitation | Advanced Materials, v.36, no.16 | - |
dc.citation.title | Advanced Materials | - |
dc.citation.volume | 36 | - |
dc.citation.number | 16 | - |
dc.type.docType | Article; Early Access | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | ADHESIVE | - |
dc.subject.keywordPlus | MICROSURGERY | - |
dc.subject.keywordPlus | INJURIES | - |
dc.subject.keywordPlus | CONDUIT | - |
dc.subject.keywordPlus | GLUE | - |
dc.subject.keywordAuthor | adhesive | - |
dc.subject.keywordAuthor | nerve repair | - |
dc.subject.keywordAuthor | neurorrhaphy | - |
dc.subject.keywordAuthor | self-healing | - |
dc.subject.keywordAuthor | stretchable | - |
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