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Sticky and Strain-Gradient Artificial Epineurium for Sutureless Nerve Repair in Rodents and Nonhuman Primates

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dc.contributor.authorSeong, Duhwan-
dc.contributor.authorChoi, Yeonsun-
dc.contributor.authorChoi, In Cheul-
dc.contributor.authorLee, Jaebeom-
dc.contributor.authorChoi, Jae Hyuk-
dc.contributor.authorPark, Ji Hun-
dc.contributor.authorNam, Jae Jun-
dc.contributor.authorJu, Jaewon-
dc.contributor.authorRyoo, Hyun Jae-
dc.contributor.authorKwak, Donghee-
dc.contributor.authorLee, Joonyeol-
dc.contributor.authorKim, Seong-Gi-
dc.contributor.authorKim, Dong Hwee-
dc.contributor.authorPark, Jong Woong-
dc.contributor.authorShin, Mikyung-
dc.contributor.authorSon, Donghee-
dc.date.accessioned2024-02-27T02:00:05Z-
dc.date.available2024-02-27T02:00:05Z-
dc.date.issued2024-02-
dc.identifier.issn0935-9648-
dc.identifier.issn1521-4095-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65530-
dc.description.abstractThe need for the development of soft materials capable of stably adhering to nerve tissues without any suturing followed by additional damages is at the fore at a time when success in postoperative recovery depends largely on the surgical experience and/or specialized microsuturing skills of the surgeon. Despite fully recognizing such prerequisite conditions, designing the materials with robust adhesion to wet nerves as well as acute/chronic anti-inflammation remains to be resolved. Herein, a sticky and strain-gradient artificial epineurium (SSGAE) that overcomes the most critically challenging aspect for realizing sutureless repair of severely injured nerves is presented. In this regard, the SSGAE with a skin-inspired hierarchical structure entailing strain-gradient layers, anisotropic Janus layers including hydrophobic top and hydrophilic bottom surfaces, and synergistic self-healing capabilities enables immediate and stable neurorrhaphy in both rodent and nonhuman primate models, indicating that the bioinspired materials strategy significantly contributes to translational medicine for effective peripheral nerve repair. A key feature in the materials design of wet adhesive, "a sticky and strain-gradient artificial epineurium (SSGAE) with skin-inspired hierarchical structure entailing strain-gradient layers, Janus hydrophilic/hydrophobic surfaces, and even self-healing property", which enables immediate and stable neurorrhaphy, is reported. image-
dc.language영어-
dc.language.isoENG-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.titleSticky and Strain-Gradient Artificial Epineurium for Sutureless Nerve Repair in Rodents and Nonhuman Primates-
dc.typeArticle-
dc.publisher.location독일-
dc.identifier.doi10.1002/adma.202307810-
dc.identifier.scopusid2-s2.0-85183733196-
dc.identifier.wosid001155414900001-
dc.identifier.bibliographicCitationAdvanced Materials-
dc.citation.titleAdvanced Materials-
dc.type.docTypeArticle; Early Access-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalResearchAreaPhysics-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPhysics, Applied-
dc.relation.journalWebOfScienceCategoryPhysics, Condensed Matter-
dc.subject.keywordPlusADHESIVE-
dc.subject.keywordPlusMICROSURGERY-
dc.subject.keywordPlusINJURIES-
dc.subject.keywordPlusCONDUIT-
dc.subject.keywordPlusGLUE-
dc.subject.keywordAuthoradhesive-
dc.subject.keywordAuthornerve repair-
dc.subject.keywordAuthorneurorrhaphy-
dc.subject.keywordAuthorself-healing-
dc.subject.keywordAuthorstretchable-
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Ansan Hospital (Department of Physical Medicine and Rehabilitation, Ansan Hospital)
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