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Cited 14 time in webofscience Cited 16 time in scopus
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Anxiety and depression propensities in patients with acute toxic liver injury

Authors
Suh, Jeong IllSakong, Jeong KyuLee, KwanLee, Yong KookPark, Jeong BaeKim, Dong JoonSeo, Yeon SeokLee, Jae DongKo, Soon YoungLee, Byung SeokKim, Seok HyunKim, Byung SeokKim, Young SeokLee, Heon JuKim, In HeeSohn, Joo HyunKim, Tae YeobAhn, Byung Min
Issue Date
Dec-2013
Publisher
Baishideng Publishing Group
Keywords
Liver injury; Herb; Toxic; Anxiety; Depression
Citation
World Journal of Gastroenterology, v.19, no.47, pp.9069 - 9076
Indexed
SCIE
SCOPUS
Journal Title
World Journal of Gastroenterology
Volume
19
Number
47
Start Page
9069
End Page
9076
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/10044
DOI
10.3748/wjg.v19.i47.9069
ISSN
1007-9327
Abstract
AIM: To investigate anxiety and depression propensities in patients with toxic liver injury. METHODS: The subjects were divided into three groups: a healthy control group (Group 1, n = 125), an acute non-toxic liver injury group (Group 2, n = 124), and a group with acute toxic liver injury group caused by non-commercial herbal preparations (Group 3, n = 126). These three groups were compared and evaluated through questionnaire surveys and using the Hospital Anxiety-Depression Scale (HADS), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and the hypochondriasis scale. RESULTS: The HADS anxiety subscale was 4.9 ± 2.7, 5.0 ± 3.0 and 5.6 ± 3.4, in Groups 1, 2, and 3, respectively. The HADS depression subscale in Group 3 showed the most significant score (5.2 ± 3.2, 6.4 ± 3.4 and 7.2 ± 3.4 in Groups 1, 2, and 3, respectively) (P < 0.01 vs Group 1, P < 0.05 vs Group 2). The BAI and BDI in Group 3 showed the most significant score (7.0 ± 6.3 and 6.9 ± 6.9, 9.5 ± 8.6 and 8.8 ± 7.3, 10.7 ± 7.2 and 11.6 ± 8.5 in Groups 1, 2, and 3, respectively) (BAI: P < 0.01 vs Group 1, P < 0.05 vs Group 2) (BDI: P < 0.01 vs Group 1 and 2). Group 3 showed a significantly higher hypochondriasis score (8.2 ± 6.0, 11.6 ± 7.5 and 13.1 ± 6.5 in Groups 1, 2, and 3, respectively) (P < 0.01 vs Group 1, P < 0.05 vs Group 2). CONCLUSION: Psychological factors that present vulnerability to the temptation to use alternative medicines, such as herbs and plant preparations, are important for understanding toxic liver injury.
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Seo, Yeon Seok
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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