Long-term immunogenicity of the influenza vaccine at reduced intradermal and full intramuscular doses among healthy young adults
- Authors
- Song, Joon Young; Kim, Woo Joo; Noh, Ji Yun; Cheong, Hee Jin; Choi, Won Suk; Yang, Tae Un; Seo, Yu Bin; Hong, Kyung-Wook; Kim, In Seon
- Issue Date
- Jul-2013
- Publisher
- KOREAN VACCINE SOC
- Keywords
- Vaccines; Influenza vaccines; Immunogenicity; Intradermal injections; Adult
- Citation
- Clinical and Experimental Vaccine Research, v.2, no.2, pp 115 - 119
- Pages
- 5
- Journal Title
- Clinical and Experimental Vaccine Research
- Volume
- 2
- Number
- 2
- Start Page
- 115
- End Page
- 119
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/10539
- DOI
- 10.7774/cevr.2013.2.2.115
- ISSN
- 2287-3651
2287-366X
- Abstract
- Purpose
To prepare for vaccine shortages under an influenza pandemic, several antigen-sparing strategies have been investigated. This study was aimed to evaluate the immunogenicity of influenza vaccine at reduced intradermal and full intramuscular dose.
Materials and Methods
We compared the effect of one-fifth and one-half intradermal doses to the full intramuscular dose on immunogenicity in healthy young adults, using a commercial influenza vaccine. A hemagglutination inhibition assay was used to compare the immunogenicity of the vaccination methods.
Results
The one-fifth intradermal dose (3 µg hemagglutinin antigen, HA) was given to 30 participants, the one-half intradermal dose (7.5 µg HA) was given to 30, and the full intramuscular dose (15 µg HA) was given to 32. No significant differences among injection routes and dosages were seen for seroprotection rate, seroconversion rate, or geometric mean titer (GMT) fold-increase for A/H1N1, A/H3N2, and B at around 4 weeks from vaccination. Although GMT for influenza B was significantly lower at six months for the one-fifth intradermal vaccination compared to the full-dose intramuscular vaccination (32.8 vs. 63.2, p=0.048), all three groups met the Evaluation of Medicinal Products (EMA) immunogenicity criteria through 1 to 6 months.
Conclusion
Intradermal administration of a one-fifth dose of influenza vaccine elicited antibody responses comparable to the intradermal one-half dose and a conventional intramuscular vaccination at 1 month post-vaccination. The immunogenicity of the one-fifth intradermal dose was sufficient to meet the requirement for the EMA criteria at six months after influenza vaccination.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Infectious Diseases > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.