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Cited 13 time in webofscience Cited 15 time in scopus
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Computed tomography findings for predicting severe acute hepatitis with prolonged cholestasisopen access

Authors
Park, Sang JungKim, Jin DongSeo, Yeon SeokPark, Beom JinKim, Min JuUm, Soon HoKim, Chang HaYim, Hyung JoonBaik, Soon KooJung, Jin YongKeum, BoraJeen, Yoon TaeLee, Hong SikChun, Hoon JaiKim, Chang DuckRyu, Ho Sang
Issue Date
Apr-2013
Publisher
BAISHIDENG PUBLISHING GROUP INC
Keywords
Acute hepatitis; Cholestasis; Computed tomography; Prognosis; Gallbladder
Citation
WORLD JOURNAL OF GASTROENTEROLOGY, v.19, no.16, pp.2543 - 2549
Indexed
SCIE
SCOPUS
Journal Title
WORLD JOURNAL OF GASTROENTEROLOGY
Volume
19
Number
16
Start Page
2543
End Page
2549
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/10799
DOI
10.3748/wjg.v19.i16.2543
ISSN
1007-9327
Abstract
AIM: To evaluate the significance of computed tomography (CT) findings in relation to liver chemistry and the clinical course of acute hepatitis. METHODS: Four hundred and twelve patients with acute hepatitis who underwent enhanced CT scanning were enrolled retrospectively. Imaging findings were analyzed for the following variables: gallbladder wall thickness (GWT), arterial heterogeneity, periportal tracking, number and maximum size of lymph nodes, presence of ascites, and size of spleen. The serum levels of alanine aminotransferase, alkaline phosphatase, bilirubin, albumin, and prothrombin time were measured on the day of admission and CT scan, and laboratory data were evaluated every 2-4 d for all subjects during hospitalization. RESULTS: The mean age of patients was 34.4 years, and the most common cause of hepatitis was hepatitis A virus (77.4%). The mean GWT was 5.2 mm. The number of patients who had findings of arterial heterogeneity, periportal tracking, lymph node enlargement > 7 mm, and ascites was 294 (80.1%), 348 (84.7%), 346 (84.5%), and 56 (13.6%), respectively. On multivariate logistic regression, male gender [odds ratio (OR) = 2.569, 95% CI: 1.477-4.469, P = 0.001], toxic hepatitis (OR = 3.531, 95% CI: 1.444-8.635, P = 0.006), level of albumin (OR = 2.154, 95% CI: 1.279-3.629, P = 0.004), and GWT (OR = 1.061, 95% CI: 1.015-1.110, P = 0.009) were independent predictive factors for severe hepatitis. The level of bilirubin (OR = 1.628, 95% CI: 1.331-1.991, P < 0.001) and GWT (OR = 1.172, 95% CI: 1.024-1.342, P = 0.021) were independent factors for prolonged cholestasis in multivariate analysis. CONCLUSION: In patients with acute hepatitis, GWT on CT scan was an independent predictor of severe hepatitis and prolonged cholestasis. (C) 2013 Baishideng. All rights reserved.
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2. Clinical Science > Department of Radiology > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Chun, Hoon Jai
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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