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말기 암환자에서 전신적 염증반응증후군의 구성요소와 혈장 내독소와의 연관성The Correlation of Plasma Endotoxin and Components of Systemic Inflammatory Response Syndrome in Terminally Ill Cancer Patients

Other Titles
The Correlation of Plasma Endotoxin and Components of Systemic Inflammatory Response Syndrome in Terminally Ill Cancer Patients
Authors
정회현윤호민최윤선이준영연종은
Issue Date
Apr-2013
Publisher
대한임상노인의학회
Keywords
Terminal cancer patients; SIRS; MOF; Endotoxin; Inflammation indices
Citation
임상노인의학회지, v.14, no.1, pp.39 - 48
Journal Title
임상노인의학회지
Volume
14
Number
1
Start Page
39
End Page
48
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/10824
ISSN
1229-6538
Abstract
Background: Most of terminally ill cancer patients died of multiple organ failure (MOF) preceding Systemic inflammatory response syndrome (SIRS). Serum endotoxin known as the cause of multiple organ failure and shock, stimulates the secretion of various cytokines and acute phase reactants. This study will investigate the correlation between the endotoxin and inflammation indices by the degree of the systemic inflammation of terminal cancer patients. Methods: Fifty-nine out of sixty-six terminally ill cancer patients referred to palliative care center, Korea University Guro Hospital from April 2009 to October 2009 were analyzed in this study. We performed correlation analysis between the plasma endotoxin and inflammation indices in the degree of the systemic inflammation. Results: As increasing the number of SIRS components, CRP were increased (r=.300, P<0.05) whereas lymphocyte was decreased(r=?.332, P<0.01). The plasma endotoxin and ESR do not demonstrate any significant correlations with the number of SIRS components. Conclusion: Lymphocyte, and CRP correlate with the degree of systemic inflammatory condition of terminally ill cancer patients. However, the plasma endotoxin concentration does not show the correlation with the states of systemic inflammation as well as with other inflammation indices.
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2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
1. Basic Science > Department of Biostatistics > 1. Journal Articles
2. Clinical Science > Department of Family Medicine > 1. Journal Articles

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Choi, Youn Seon
Guro Hospital (Department of Family Medicine, Guro Hospital)
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