Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status: the Korean Sarcopenic Obesity Study
- Authors
- Kim, Tae Nyun; Park, Man Sik; Lim, Kang Il; Choi, Hae Yoon; Yang, Sae Jeong; Yoo, Hye Jin; Kang, Hyun Joo; Song, Wook; Choi, Hyuk; Baik, Sei Hyun; Choi, Dong Seop; Choi, Kyung Mook
- Issue Date
- Apr-2013
- Publisher
- WILEY-BLACKWELL
- Citation
- CLINICAL ENDOCRINOLOGY, v.78, no.4, pp 525 - 532
- Pages
- 8
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- CLINICAL ENDOCRINOLOGY
- Volume
- 78
- Number
- 4
- Start Page
- 525
- End Page
- 532
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/10874
- DOI
- 10.1111/j.1365-2265.2012.04433.x
- ISSN
- 0300-0664
1365-2265
- Abstract
- Objective It has been suggested that insulin resistance, low-grade inflammation and vitamin D deficiency are associated with obesity and sarcopenia. However, their relationships with sarcopenic obesity (SO) are unclear. We evaluated the impact of homoeostasis model assessment of insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hsCRP) and 25-hydroxyvitamin D (25[OH]D) levels on SO in Korean adults. Study subject/measurements This study included 493 apparently healthy adults (180 men and 313 women) enrolled in the Korean Sarcopenic Obesity Study. Sarcopenia was defined as a skeletal muscle mass index (SMI) of 1SD below the sex-specific mean value for a young reference group. Obesity was defined as a visceral fat area (VFA) 100cm2. We classified the participants into four sarcopenia/obesity groups based on both SMI and VFA. Results The prevalence of SO was 17 center dot 8% in men and 24 center dot 9% in women. In women, the SO group had higher HOMA-IR and hsCRP levels compared with the non-SO group. In men, the 25[OH]D levels were significantly lower in the SO group than the non-SO group. Both hsCRP and HOMA-IR levels were negatively correlated with SMI and positively correlated with VFA in both men and women, whereas 25[OH]D levels were positively correlated with SMI in both men and women. Multiple binary logistic regression analysis showed that HOMA-IR and 25[OH]D levels were independently associated with SO in men, while HOMA-IR and hsCRP were significant factors predicting SO in women. Conclusion Insulin resistance, inflammation and vitamin D deficiency were associated with SO in a Korean adult population.
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- Appears in
Collections - 3. Graduate School > Biomedical Research Center > 1. Journal Articles
- 2. Clinical Science > Department of Endocrinology and Metabolism > 1. Journal Articles
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