Silibinin inhibits TPA-induced cell migration and MMP-9 expression in thyroid and breast cancer cellsopen access
- Authors
- Oh, Soo-Jin; Jung, Seung Pil; Han, Jeonghun; Kim, Sangmin; Kim, Jee Soo; Nam, Seok Jin; Lee, Jeong Eon; Kim, Jung-Han
- Issue Date
- Apr-2013
- Publisher
- SPANDIDOS PUBL LTD
- Keywords
- silibinin; MMP-9; phorbol ester; thyroid cancer; breast cancer
- Citation
- ONCOLOGY REPORTS, v.29, no.4, pp 1343 - 1348
- Pages
- 6
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- ONCOLOGY REPORTS
- Volume
- 29
- Number
- 4
- Start Page
- 1343
- End Page
- 1348
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/10886
- DOI
- 10.3892/or.2013.2252
- ISSN
- 1021-335X
1791-2431
- Abstract
- Matrix metalloproteinases (MMPs) play an important role in cancer metastasis, cell migration and invasion. Herein, we investigated the effects of silibinin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell migration and MMP-9 expression in thyroid and breast cancer cells. Our results revealed that the levels of MMP-9 mRNA and protein expression were significantly increased by TPA but not MMP-2 in TPC-1 and MCF7 cells. To verify the regulatory mechanism of TPA-induced MMP-9 expression, we treated TPC-1 and MCF7 cells with the MEK1/2 inhibitor, UO126, and TPA-induced MMP-9 expression was significantly decreased. We also found that TPA-induced cell migration and MMP-9 expression was significantly decreased by silibinin. In addition, TPA-induced phosphorylation of MEK and ERK was also inhibited by silibinin. Taken together, we suggest that silibinin suppresses TPA-induced cell migration and MMP-9 expression through the MEK/ERK-dependent pathway in thyroid and breast cancer cells.
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- Appears in
Collections - 2. Clinical Science > Department of Anesthesiology and Pain Medicine > 1. Journal Articles
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