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Cited 24 time in webofscience Cited 23 time in scopus
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Clinical features of autoimmune hepatitis and comparison of two diagnostic criteria in Korea: A nationwide, multicenter study

Authors
Kim, Bo HyunKim, Yoon JunJeong, Sook-HyangTak, Won YoungAhn, Sang HoonLee, Youn JaeJung, Eun UkIl Lee, JungYeon, Jong EunHwang, Jae SeokUm, Soon HoSeo, Yeon SeokKim, Young SeokSong, Byung CheolKim, Ju HyunJung, Young KulPark, Choong KeeKim, Kyung-AhMin, Hyun JuCho, Eun YoungLee, Eom SeokKwon, So YoungChae, Hee BokKim, Dong JoonShin, Su Rin
Issue Date
Jan-2013
Publisher
WILEY
Keywords
autoimmune hepatitis; diagnosis; diagnostic criteria; treatment
Citation
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.28, no.1, pp.128 - 134
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume
28
Number
1
Start Page
128
End Page
134
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/11075
DOI
10.1111/j.1440-1746.2012.07292.x
ISSN
0815-9319
Abstract
Background and Aim: As a rare liver disease, little is known about autoimmune hepatitis (AIH). This study investigated the clinical features and compared two diagnostic criteria of AIH in Korea. Methods: A nationwide, multicenter, retrospective analysis was done of data of adult patients diagnosed with AIH from January 2005 to December 2009. Results: The enrolled patients (n = 343; mean age, 52.8 years; range, 19-87 years; 12% male, 88% female) met diagnostic criteria of AIH according to the revised original criteria (n = 311) or the simplified criteria (n = 250). At diagnosis, 30.6% were asymptomatic, 22.7% were cirrhotic, and 4.3% displayed hepatic decompensation. The positive results for anti-nuclear antibody, smooth muscle antibody, and anti-liver/kidney microsomal antibody were 94.2%, 23.0%, and 2.9%, respectively. Definite AIH and probable AIH according to the revised original criteria were 24.8% and 65.3%, respectively, while those according to the simplified criteria were 34.4% and 38.5%, respectively. The diagnostic sensitivity and positive predictive value of simplified criteria in comparison with the revised original criteria were 69.9% and 86.4%, respectively. As an initial therapy, corticosteroid (37.7%) or corticosteroid with azathioprine (36.8%) was administered. Remission, incomplete response, and treatment failure were noted with 85.7%, 10.5%, and 3.9% of patients, respectively. Conclusions: Autoimmune hepatitis in Korea is mostly type I, showing a mean age of 53 years with comparable clinical features to other countries. The concordant rate of the two diagnostic criteria was rather low with modest sensitivity of the simplified criteria. Further studies on the validation of the diagnostic criteria are warranted.
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Jung, Young Kul
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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