Comparative Study of Helicobacter pylori Eradication Rates With 5-day Quadruple "Concomitant" Therapy and 7-day Standard Triple Therapy
- Kim, Seung Young; Lee, Sang Woo; Hyun, Jong Jin; Jung, Sung Woo; Koo, Ja Seol; Yim, Hyung Joon; Park, Jong Jae; Chun, Hoon Jai; Choi, Jai Hyun
- Issue Date
- LIPPINCOTT WILLIAMS & WILKINS
- Helicobacter pylori; drug therapy; combination; concomitant therapy
- JOURNAL OF CLINICAL GASTROENTEROLOGY, v.47, no.1, pp.21 - 24
- Journal Title
- JOURNAL OF CLINICAL GASTROENTEROLOGY
- Start Page
- End Page
- Background: Several studies have shown the superiority of concomitant quadruple therapy containing 3 antibiotics over triple therapy for Helicobacter pylori infection. The aim of this study was to compare concomitant quadruple therapy with standard triple therapy for first-line H. pylori eradication. Methods: A total of 270 patients with proven H. pylori infection were randomly assigned to one of 2 regimens: amoxicillin 1000mg with clarithromycin 500mg and lansoprazole 30mg twice daily for 7 days (triple therapy) or amoxicillin 1000mg with clarithromycin 500mg, metronidazole 500mg, and lansoprazole 30mg twice daily for 5 days (concomitant therapy). The success of eradication was evaluated 4 to 5 weeks after completion of treatment. Results: Eradication rates were 86.1% in the triple therapy and 91.4% in the concomitant therapy (per protocol), but the difference was not statistically significant. Mild adverse events were more frequently reported in the concomitant-therapy group (35.6%) than in the triple-therapy group (25.2%) (P=0.09). Conclusions: Five-day quadruple concomitant therapy eradicated H. pylori in over 90% of patients. Accordingly, concomitant therapy is thought to be a promising alternative to triple therapy as a first-line treatment regimen for H. pylori eradication.
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- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
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