Detailed Information

Cited 34 time in webofscience Cited 36 time in scopus
Metadata Downloads

Comparative Study of Helicobacter pylori Eradication Rates With 5-day Quadruple "Concomitant" Therapy and 7-day Standard Triple Therapy

Authors
Kim, Seung YoungLee, Sang WooHyun, Jong JinJung, Sung WooKoo, Ja SeolYim, Hyung JoonPark, Jong JaeChun, Hoon JaiChoi, Jai Hyun
Issue Date
Jan-2013
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
Helicobacter pylori; drug therapy; combination; concomitant therapy
Citation
JOURNAL OF CLINICAL GASTROENTEROLOGY, v.47, no.1, pp.21 - 24
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF CLINICAL GASTROENTEROLOGY
Volume
47
Number
1
Start Page
21
End Page
24
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/11079
DOI
10.1097/MCG.0b013e3182548ad4
ISSN
0192-0790
Abstract
Background: Several studies have shown the superiority of concomitant quadruple therapy containing 3 antibiotics over triple therapy for Helicobacter pylori infection. The aim of this study was to compare concomitant quadruple therapy with standard triple therapy for first-line H. pylori eradication. Methods: A total of 270 patients with proven H. pylori infection were randomly assigned to one of 2 regimens: amoxicillin 1000mg with clarithromycin 500mg and lansoprazole 30mg twice daily for 7 days (triple therapy) or amoxicillin 1000mg with clarithromycin 500mg, metronidazole 500mg, and lansoprazole 30mg twice daily for 5 days (concomitant therapy). The success of eradication was evaluated 4 to 5 weeks after completion of treatment. Results: Eradication rates were 86.1% in the triple therapy and 91.4% in the concomitant therapy (per protocol), but the difference was not statistically significant. Mild adverse events were more frequently reported in the concomitant-therapy group (35.6%) than in the triple-therapy group (25.2%) (P=0.09). Conclusions: Five-day quadruple concomitant therapy eradicated H. pylori in over 90% of patients. Accordingly, concomitant therapy is thought to be a promising alternative to triple therapy as a first-line treatment regimen for H. pylori eradication.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Sang Woo photo

Lee, Sang Woo
안산병원 (Department of Gastroenterology and Hepatology, Ansan Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE