Strategy for developing medical arsenals by modulation of membrane fusion activity of influenza virus hemagglutinin
- Authors
- Lee S.; Kim J.I.; Lee I.; Park M.-S.
- Issue Date
- 2013
- Publisher
- The Korean Society for Mocrobiology / The Korean Society of Virology
- Keywords
- Fusion inhibitor; Hemagglutinin; Influenza; Membrane fusion
- Citation
- Journal of Bacteriology and Virology, v.43, no.4, pp 337 - 341
- Pages
- 5
- Indexed
- SCOPUS
KCI
- Journal Title
- Journal of Bacteriology and Virology
- Volume
- 43
- Number
- 4
- Start Page
- 337
- End Page
- 341
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/11334
- DOI
- 10.4167/jbv.2013.43.4.337
- ISSN
- 1598-2467
2093-0429
- Abstract
- Influenza virus is a serious pathogen that burdens society with health care costs, and can lead to fatality. The virus is dealt with currently by vaccination and anti-influenza drugs. However, vaccines need to be improved towards safer and more efficient production formats, and drugs need to be constantly renewed to cope with resistances. That the neuraminidase inhibitors are only drugs currently available warrants urgent attention to an alternative anti-influenza target. In this paper we introduce studies on fusion activity of influenza virus hemagglutinin (HA), and discuss how to best utilize the knowledge for an improved vaccine development and an anti-influenza drug search. Potential application of mutations resulting in changes in fusion activity to cell culture optimized vaccine virus development and strategies to develop broad spectrum anti-influenza drugs through targeting the conserved fusion domain of the HA are discussed.
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- Appears in
Collections - 1. Basic Science > Department of Microbiology > 1. Journal Articles
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