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The Impact of Inosine Triphosphatase Variants on Hemoglobin Level and Sustained Virologic Response of Chronic Hepatitis C in Koreanopen access

Authors
Kim J.S.Ahn S.-M.Jung Y.K.Kwon Y.K.J.Kim Y.S.Choi D.J.Kim J.H.
Issue Date
2013
Keywords
Anemia; Chronic; Hepatitis C; Il28b; Itpa; Ribavirin
Citation
Journal of Korean Medical Science, v.28, no.8, pp.1213 - 1219
Indexed
SCIE
SCOPUS
KCI
Journal Title
Journal of Korean Medical Science
Volume
28
Number
8
Start Page
1213
End Page
1219
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/11352
DOI
10.3346/jkms.2013.28.8.1213
ISSN
1011-8934
Abstract
Two variants of the inosine triphosphatase (ITPA: rs1127354, rs7270101) gene cause ITPA deficiency and protect against the hemolytic toxicity of ribavirin. We investigated the clinical significance of ITPA variants in Korean patients treated with pegylated interferon (PEG-IFN) plus ribavirin. Of the 133 patients, 108 were CC and 25 were non-CC at rs1127354 (groups A and B, respectively). On the other hand, at rs7270101 all 133 were AA. The mean values of Hemoglobin (Hgb) after 4, 8, and 12 weeks of treatment in groups A and B were 12.2 and 14.0, 11.8 and 13.2, and 11.5 and 12.9, respectively (P = 0.001, 0.036, 0.036). Sustained virologic response (SVR) was achieved in 67.8% (40/59) of genotype 1 patients and in 75% (27/36) of non-genotype 1 patients. Regarding ITPA variants, SVR was achieved by 66% and 80% of genotype 1 (P = 0.282), and by 78% and 71% (P = 0.726) of non-genotype 1. SVR was not significantly different in groups A and B. In conclusion, non-CC at rs1127354 without involvement of rs7270101 is strongly associated with protection from ribavirin-induced anemia, however, ITPA genotype is not associated with SVR. © 2013 The Korean Academy of Medical Sciences.
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Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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