Real-time phase-contrast imaging of photothermal treatment of head and neck squamous cell carcinoma: an in vitro study of macrophages as a vector for the delivery of gold nanoshells
- Authors
- Yang, Taeseok Daniel; Choi, Wonshik; Yoon, Tai Hyun; Lee, Kyoung Jin; Lee, Jae-Seung; Han, Sang Hun; Lee, Min-Goo; Yim, Hong Soon; Choi, Kyung Min; Park, Min Woo; Jung, Kwang-Yoon; Baek, Seung-Kuk
- Issue Date
- Dec-2012
- Publisher
- SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
- Keywords
- real-time imaging; photothermal treatment; macrophage; gold nanoshells; squamous cell carcinoma
- Citation
- JOURNAL OF BIOMEDICAL OPTICS, v.17, no.12
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- JOURNAL OF BIOMEDICAL OPTICS
- Volume
- 17
- Number
- 12
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/11511
- DOI
- 10.1117/1.JBO.17.12.128003
- ISSN
- 1083-3668
1560-2281
- Abstract
- Photothermal treatment (PTT) using nanoparticles has gained attention as a promising alternative therapy for malignant tumors. One strategy for increasing the selectivity of PTT is the use of macrophages as a cellular vector for delivering nanoparticles. The aim of the present study is to examine the use of macrophages as a cellular vector for efficient PTT and determine the appropriate irradiation power and time of a near-infrared (NIR) laser using realtime phase-contrast imaging. Thermally induced injury and death of cancer cells were found to begin at 44 degrees C to 45 degrees C, which was achieved using the PTT effect with gold nanoshells (NS) and irradiation with a NIR laser at a power of 2 W for 5 min. The peritoneal macrophage efficiently functioned as a cellular vector for the NS, and the cancer cells surrounding the NS-loaded macrophages selectively lost their cellular viability after being irradiated with the NIR laser. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.12.128003]
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- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Otorhinolaryngology-Head and Neck Surgery > 1. Journal Articles
- 1. Basic Science > Department of Physiology > 1. Journal Articles
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