Detailed Information

Cited 32 time in webofscience Cited 32 time in scopus
Metadata Downloads

Psychometric Hepatic Encephalopathy Score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis

Authors
Seo, Yeon SeokYim, Sun YoungJung, Jin YongKim, Chang HaKim, Jin DongKeum, BoraAn, HyongginYim, Hyung JoonLee, Hong SikKim, Chang DuckRyu, Ho SangUm, Soon Ho
Issue Date
Nov-2012
Publisher
WILEY-BLACKWELL
Keywords
ammonia; encephalopathy; neuropsychological; normogram
Citation
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.27, no.11, pp.1695 - 1704
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume
27
Number
11
Start Page
1695
End Page
1704
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/11593
DOI
10.1111/j.1440-1746.2012.07217.x
ISSN
0815-9319
Abstract
Background and Aim: Although the Psychometric Hepatic Encephalopathy Score (PHES) for the diagnosis of minimal hepatic encephalopathy (MHE) has been validated in several countries, further validation is required for its use in different populations. The aims of this study were thus to standardize the PHES in a healthy Korean population and evaluate the prevalence of MHE among Korean patients with liver cirrhosis. Methods: Two-hundred healthy subjects without evidence of liver disease and 160 patients with liver cirrhosis without overt HE were included. Blood sampling for routine laboratory tests and determination of venous ammonia concentration was performed on the day of PHES neuropsychological testing. Results: The age and education years of the control group were 41 +/- 13 years and 13 +/- 3 years, respectively; 100 of the subjects (50.0%) were men. The PHES for the control group was -0.31 +/- 2.06 and the normal range was thus set at > -5 points. The age and education years of the liver cirrhosis group were 55 +/- 8 and 11 +/- 4 years, respectively; 102 of those in this group (63.8%) were men. Of the liver cirrhosis patients, 129 (80.6%), 21 (13.1%), and 10 (6.3%) had ChildPugh grades A, B, and C, respectively. The PHES of the liver cirrhosis group was -2.94 +/- 3.39. MHE was diagnosed in 41 patients (25.6%), of which 26 (20.2%), nine (42.9%), and six (60.0%) had ChildPugh grades A, B, and C, respectively. Conclusions: The PHES was useful for detecting patients with MHE. A significant proportion of Korean patients with liver cirrhosis suffer from MHE.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
1. Basic Science > Department of Biostatistics > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Seo, Yeon Seok photo

Seo, Yeon Seok
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE