Detailed Information

Cited 152 time in webofscience Cited 165 time in scopus
Metadata Downloads

A Prospective Nationwide Study of Drug-Induced Liver Injury in Korea

Authors
Suk, Ki TaeKim, Dong JoonKim, Chang HoonPark, Seung HaYoon, Jai HoonKim, Yeon SooBaik, Gwang HoKim, Jin BongKweon, Young OhKim, Byung IkKim, Seok HyunKim, In HeeKim, Ju HyunNam, Soon WooPaik, Yong HanSuh, Jeong IllSohn, Joo HyunAhn, Byung MinUm, Soon HoLee, Heon JuCho, MongJang, Myoung KukChoi, Sung KyuHwang, Seong GyuSung, Ho TaikChoi, Jong YoungHan, Kwang Hyub
Issue Date
Sep-2012
Publisher
NATURE PUBLISHING GROUP
Keywords
CAUSALITY ASSESSMENT; CLINICAL-PRACTICE; UNITED-STATES; RECHALLENGE; NETWORK
Citation
AMERICAN JOURNAL OF GASTROENTEROLOGY, v.107, no.9, pp 1380 - 1387
Pages
8
Indexed
SCI
SCIE
SCOPUS
Journal Title
AMERICAN JOURNAL OF GASTROENTEROLOGY
Volume
107
Number
9
Start Page
1380
End Page
1387
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/11833
DOI
10.1038/ajg.2012.138
ISSN
0002-9270
1572-0241
Abstract
OBJECTIVES: To address a growing concern about drug-induced liver injury (DILI), a nationwide study was performed to investigate the significance of DILI in Korea. METHODS: From May 2005 to May 2007, cases of DILI (alanine transferase >3xupper normal limit or total bilirubin >2xupper normal limit) from 17 referral university hospitals were prospectively enrolled. Adjudication by the seven review boards was considered for the confirmation of causality and the Roussel Uclaf Causality Assessment Method (RUCAM) scale was used. RESULTS: A total of 371 cases were diagnosed with DILI. The extrapolated incidence of hospitalization at university hospital in Korea was 12/100,000 persons/year. The causes included "herbal medications " (102, 27.5%), "prescription or non-prescription medications" (101, 27.3%), "health foods or dietary supplements" (51, 13.7%), "medicinal herbs or plants" (35, 9.4%), " folk remedies " (32, 8.6%), " combined" (30, 8.2%), "herbal preparations" (12, 3.2%), and others (8, 2.2%). Nine cases were linked to acetaminophen. The frequencies of hepatocellular, mixed, and cholestatic types were 76.3, 14.8, and 8.9%, respectively. A total of 234 cases met the criteria for Hy's law. Five patients died or underwent transplantation. Twenty-five cases (21 herbs and 4 medications) did not meet the time-to-onset criteria of the RUCAM. CONCLUSIONS: DILI appears to be a highly relevant health problem in Korea. "Herbal medications " are the principal cause of DILI. A more objective and reproducible causality assessment tool is strongly desired as the RUCAM scale frequently undercounts the cases caused by herbs owing to a lack of previous information and incompatible time criteria.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE