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Cited 10 time in webofscience Cited 17 time in scopus
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Changes in sexual function and gonadal axis hormones after switching to aripiprazole in male schizophrenia patients: a prospective pilot study

Authors
Jeong, Hyun-GhangLee, Moon-SooLee, Hwa-YoungKo, Young-HoonHan, ChangsuJoe, Sook-Haeng
Issue Date
Jul-2012
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
aripiprazole; atypical antipsychotics; erectile dysfunction; hypothalamic-pituitary-gonadal axis; prolactin; sexual dysfunction; testosterone
Citation
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, v.27, no.4, pp.177 - 183
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
Volume
27
Number
4
Start Page
177
End Page
183
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/11951
DOI
10.1097/YIC.0b013e328351c8c4
ISSN
0268-1315
Abstract
Antipsychotic-induced sexual dysfunction is a common problem in patients with schizophrenia. The aim of the study was to investigate the effect of switching to aripiprazole on sexual dysfunction and the hypothalamic-pituitary-gonadal axis in male patients with schizophrenia. In this prospective, open-label study, the participants were 10 male schizophrenia patients treated with atypical antipsychotics, risperidone, amisulpride, and olanzapine. Before and after switching to aripiprazole, they were assessed on the Arizona Sexual Experience Scale, and hormonal levels were measured. Our results showed a significant improvement in the severity of sexual dysfunction, especially in 'ease of sexual arousal' and 'penile erection,' as measured by the Arizona Sexual Experience Scale total scores after switching to aripiprazole (chi(2) = 12.45 and P = 0.002). The serum prolactin level decreased significantly after switching to aripiprazole (chi(2) = 11.14 and P = 0.004), but the changes in the total testosterone level were not significant (chi(2) = 4.75 and P = 0.93). Our results suggest that sexual dysfunction in schizophrenia patients seems to improve after switching to aripiprazole from other atypical antipsychotics (risperiodone, amisulpride, or olanzapine). This may be associated with a change in dopamine and serotonin transmissions and a decrease in the serum prolactin concentration. Int Clin Psychopharmacol 27:177-183 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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Jeong, Hyun Ghang
Guro Hospital (Department of Psychiatry, Guro Hospital)
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